Balance between Hyperinflammation and Immunosuppression in Sepsis

Hemang Yadav, Rodrigo Cartin-Ceba

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Sepsis is a major cause of morbidity and mortality among hospitalized patients and the leading cause of death among patients admitted to intensive care units. The immune response in sepsis is characterized by the activation of both proinflammatory and anti-inflammatory pathways. These pathways are concurrent, starting early in the course of sepsis. Given the high burden of morbidity and mortality associated with sepsis, there is an increasing interest in immunomodulatory therapies targeted at improving outcomes in sepsis. This review will summarize current understanding about the balance between hyperinflammation and immunosuppression in sepsis and discuss the role of potential therapies to modulate these responses.

Original languageEnglish (US)
Pages (from-to)42-50
Number of pages9
JournalSeminars in Respiratory and Critical Care Medicine
Issue number1
StatePublished - Feb 1 2016


  • glucocorticoid
  • immunology
  • immunosuppression
  • sepsis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine


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