B cell lymphoma 10 is essential for FcεR-mediated degranulation and IL-6 production in mast cells

Yuhong Chen, Bhanu P. Pappu, Hu Zeng, Liquan Xue, Stephan W. Morris, Xin Lin, Renren Wen, Demin Wang

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


The adaptor protein B cell lymphoma 10 (Bcl10) plays an essential role in the functions of the AgRs in T and B cells. In this study, we report that Bcl10 also plays an important role in mast cells. Bcl10 is expressed in mast cells. Although Bcl10-deficient mast cells undergo normal development, we demonstrate that Bcl10 is essential for specific functions of FceR. Although Bcl10-deficient mast cells have normal de novo synthesis and release of the lipid mediator arachidonic acid, the mutant cells possess impaired FcεR-mediated degranulation, indicated by decreased serotonin release, and impaired cytokine production, measured by release of IL-6. In addition, Bcl10-deficient mice display impaired IgE-mediated passive cutaneous anaphylaxis. Moreover, although Bcl10-deficient mast cells have normal FcεR-mediated Ca2+ flux, activation of PI3K, and activation of the three types of MAPKs (ERKs, JNK, and p38), the mutant cells have markedly diminished FcεR-mediated activation of NF-κB and decreased activation of AP-1. Thus, Bcl10 is essential for FcεR-induced activation of AP-1, NF-κB, degranulation, and cytokine production in mast cells.

Original languageEnglish (US)
Pages (from-to)49-57
Number of pages9
JournalJournal of Immunology
Issue number1
StatePublished - Jan 1 2007

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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