TY - JOUR
T1 - Awake craniotomy vs craniotomy under general anesthesia for perirolandic gliomas
T2 - Evaluating perioperative complications and extent of resection
AU - Eseonu, Chikezie I.
AU - Rincon-Torroella, Jordina
AU - ReFaey, Karim
AU - Lee, Young M.
AU - Nangiana, Jasvinder
AU - Vivas-Buitrago, Tito
AU - Quiñones-Hinojosa, Alfredo
N1 - Publisher Copyright:
© 2017 by the Congress of Neurological Surgeons.
PY - 2017/9/1
Y1 - 2017/9/1
N2 - Background: A craniotomy with direct cortical/subcortical stimulation either awake or under general anesthesia (GA) present 2 approaches for removing eloquent region tumors. With a reported higher prevalence of intraoperative seizures occurring during awake resections of perirolandic lesions, oftentimes, surgery under GA is chosen for these lesions. Objective: To evaluate a single-surgeon's experience with awake craniotomies (AC) vs surgery under GA for resecting perirolandic, eloquent, motor-region gliomas. Methods: Between 2005 and 2015, a retrospective analysis of 27 patients with perirolandic, eloquent, motor-area gliomas that underwent an AC were case-control matched with 31 patients who underwent surgery under GA for gliomas in the same location. All patients underwent direct brain stimulation with neuromonitoring and perioperative risk factors, extent of resection, complications, and discharge status were assessed. Results: The postoperative Karnofsky Performance Score (KPS) was significantly lower for the GA patients at 81.1 compared to the AC patients at 93.3 (P=.040). The extent of resection for GA patients was 79.6% while the AC patients had an 86.3% resection (P = .136). There were significantly more 100% total resections in the AC patients 25.9% compared to the GA group (6.5%; P=.041). Patients in the GA group had a longer mean length of hospitalization of 7.9 days compared to the AC group at 4.2 days (P = .049). Conclusion: We show that AC can be performed with more frequent total resections, better postoperative KPS, shorter hospitalizations, as well as similar perioperative complication rates compared to surgery under GA for perirolandic, eloquent motor-region glioma.
AB - Background: A craniotomy with direct cortical/subcortical stimulation either awake or under general anesthesia (GA) present 2 approaches for removing eloquent region tumors. With a reported higher prevalence of intraoperative seizures occurring during awake resections of perirolandic lesions, oftentimes, surgery under GA is chosen for these lesions. Objective: To evaluate a single-surgeon's experience with awake craniotomies (AC) vs surgery under GA for resecting perirolandic, eloquent, motor-region gliomas. Methods: Between 2005 and 2015, a retrospective analysis of 27 patients with perirolandic, eloquent, motor-area gliomas that underwent an AC were case-control matched with 31 patients who underwent surgery under GA for gliomas in the same location. All patients underwent direct brain stimulation with neuromonitoring and perioperative risk factors, extent of resection, complications, and discharge status were assessed. Results: The postoperative Karnofsky Performance Score (KPS) was significantly lower for the GA patients at 81.1 compared to the AC patients at 93.3 (P=.040). The extent of resection for GA patients was 79.6% while the AC patients had an 86.3% resection (P = .136). There were significantly more 100% total resections in the AC patients 25.9% compared to the GA group (6.5%; P=.041). Patients in the GA group had a longer mean length of hospitalization of 7.9 days compared to the AC group at 4.2 days (P = .049). Conclusion: We show that AC can be performed with more frequent total resections, better postoperative KPS, shorter hospitalizations, as well as similar perioperative complication rates compared to surgery under GA for perirolandic, eloquent motor-region glioma.
KW - Anesthesia
KW - Awake craniotomy
KW - Cortical stimulation mapping
KW - Glioblastoma
KW - Glioma
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U2 - 10.1093/neuros/nyx023
DO - 10.1093/neuros/nyx023
M3 - Article
AN - SCOPUS:85042064875
SN - 0148-396X
VL - 81
SP - 481
EP - 489
JO - Neurosurgery
JF - Neurosurgery
IS - 3
ER -