Autonomic dysfunction in peripheral nerve disease

Phillip A. Low, Steven Vernino, Guillermo Suarez

Research output: Contribution to journalReview articlepeer-review

94 Scopus citations


Autonomic neuropathies are inherited or acquired neuropathies in which autonomic nerve fibers are selectively or disproportionately affected. Generally, sympathetic and parasympathetic fibers are both affected but there are exceptions. Acquired cases can be autoimmune; due to diabetes, amyloidosis, drugs, or toxins; or idiopathic. Autoimmune autonomic neuropathy is often subacute, sometimes associated with a neo-plasm, and associated with high titers of antibody to ganglionic nicotinic acetylcholine receptor in about half of the severe cases. The molecular basis of inherited autonomic neuropathies is better known, including recent identification of the loci and genes of hereditary sensory and autonomic neuropathies types I, III, and IV. The inherited amyloid neuropathies are due to mutations of three proteins: transthyretin, apolipoprotein A1, and gelsolin. Non-invasive autonomic testing complements clinical and electrophysiological characterization of the autonomic neuropathies.

Original languageEnglish (US)
Pages (from-to)646-661
Number of pages16
JournalMuscle and Nerve
Issue number6
StatePublished - Jun 1 2003


  • Autoimmune autonomic neuropathy
  • Autonomic
  • Ganglionic antibody
  • Paraneoplastic
  • Thermoregulatory sweat test

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)


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