TY - JOUR
T1 - Autologous cell-based therapies for vascular disease
AU - Gulati, Rajiv
AU - Simari, Robert D.
N1 - Funding Information:
The authors extend appreciation to Traci Paulson for secretarial support during manuscript preparation. They would like to recognize research support from the National Institutes of Health (HL65191 and HL075566 to R.D.S.), the American Heart Association (0325543Z to R.G.), and the Mayo Foundation. R.D.S. is an Established Investigator of the American Heart Association.
PY - 2004/10
Y1 - 2004/10
N2 - Strategies that enhance the number of endothelial cells (ECs) in the vessel wall following injury may limit complications such as thrombosis, vasospasm, and neointimal formation through reconstitution of a luminal barrier and cellular secretion of paracrine factors. Proof of principle has been demonstrated by studies in which mature ECs, culture expanded from harvested vascular tissue, were seeded in the arterial wall following balloon injury. The recent identification of circulating cells capable of developing an endothelial phenotype, including progenitor cells, has raised the possibility of using blood-derived cells as therapeutic agents. This article reviews data suggesting that such cells confer vascular protective effects after injury, raising the potential for novel, autologous approaches to the treatment of vascular disease.
AB - Strategies that enhance the number of endothelial cells (ECs) in the vessel wall following injury may limit complications such as thrombosis, vasospasm, and neointimal formation through reconstitution of a luminal barrier and cellular secretion of paracrine factors. Proof of principle has been demonstrated by studies in which mature ECs, culture expanded from harvested vascular tissue, were seeded in the arterial wall following balloon injury. The recent identification of circulating cells capable of developing an endothelial phenotype, including progenitor cells, has raised the possibility of using blood-derived cells as therapeutic agents. This article reviews data suggesting that such cells confer vascular protective effects after injury, raising the potential for novel, autologous approaches to the treatment of vascular disease.
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U2 - 10.1016/j.tcm.2004.07.004
DO - 10.1016/j.tcm.2004.07.004
M3 - Review article
C2 - 15542377
AN - SCOPUS:8144228275
SN - 1050-1738
VL - 14
SP - 262
EP - 267
JO - Trends in cardiovascular medicine
JF - Trends in cardiovascular medicine
IS - 7
ER -