Autoimmune hemolytic anemia in association with monoclonal IgM(κ) with anti-i activity

Neil E. Kay, Leo I. Gordon, Steven D. Douglas

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


A patient with a warm autoimmune hemolytic anemia with an immunoglobulin G (IgG) panagglutinin, also had monoclonal IgM(κ) cold agglutinin with anti-i activity. Ninety per cent of the peripheral blood lymphocytes had surface immunoglobulin and the number of T cells was diminished. A subpopulation of the patient's lymphocytes formed rosettes with cord (I) erythrocytes and not with adult (I) erythrocytes. The finding of increased lymphocytes bearing i-binding sites and a monoclonal antibody with anti-i activity could be related to shared idiotypic determinants between antigen-binding sites and serum antibody. The occurrence of two autoantibodies in this patient suggests an immune regulatory disorder.

Original languageEnglish (US)
Pages (from-to)845-850
Number of pages6
JournalThe American Journal of Medicine
Issue number5
StatePublished - May 1978

ASJC Scopus subject areas

  • General Medicine


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