Autoimmune heart disease

Research output: Chapter in Book/Report/Conference proceedingChapter


A combination of genetic predisposition and environmental factors contributes to the development of autoimmune disease. Autoimmune diseases can be classified as organ-specific or systemic depending on whether the autoimmune response is directed against a particular tissue like the heart, which occurs during myocarditis and dilated cardiomyopathy, or is directed against widespread antigens such as cell nuclear antigens, as often occurs in rheumatic autoimmune diseases. Most autoimmune diseases occur more frequently in women, but autoimmune heart diseases, particularly those with a cell-mediated pathogenesis, occur more often in men. Common mechanisms such as activation of Toll-like receptors and proinflammatory and profibrotic cytokines contribute to the pathogenesis of disease and likely increase the risk for women with autoimmune diseases to secondarily develop cardiovascular diseases.

Original languageEnglish (US)
Title of host publicationTranslational Autoimmunity
Subtitle of host publicationAutoimmune Diseases in Different Organs
Number of pages22
ISBN (Electronic)9780128244661
ISBN (Print)9780323859769
StatePublished - Jan 1 2022


  • Autoimmune disease
  • Dilated cardiomyopathy
  • Myocarditis
  • Rheumatic autoimmune diseases
  • Sex differences
  • Toll-like receptor 4

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)


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