Autoimmune and Paraneoplastic Myelopathies

Nicholas L. Zalewski, Eoin Flanagan

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Prompt recognition of an inflammatory myelopathy is critical, as a specific diagnosis and management plan allows for optimal patient outcomes. Many treatment options are now available for autoimmune and paraneoplastic myelopathies, but specific management strategies and expected prognosis vary widely depending on the underlying etiology. An understanding of the relevant clinical details, imaging findings, and other diagnostic information that can help achieve a specific myelopathy diagnosis and treatment plan is essential for all neurologists, given the variety of contexts in which myelopathies are encountered. We provide an outline of the diagnostic evaluation and treatment of various inflammatory myelopathies seen in autoimmune and paraneoplastic diseases, including multiple sclerosis, aquaporin-4 immunoglobulin G (IgG) seropositive neuromyelitis optica spectrum disorder, sarcoidosis, myelin oligodendrocyte glycoprotein IgG associated disease, and other rare inflammatory myelopathies; we also highlight common mimickers of inflammatory myelopathies.

Original languageEnglish (US)
Pages (from-to)278-289
Number of pages12
JournalSeminars in Neurology
Issue number3
StatePublished - Jun 1 2018


  • neuromyelitis optica
  • spinal cord
  • transverse myelitis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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