Abstract
To better understand genetic alterations in atypical adenomatous hyperplasia (AAH) of the prostate, we examined the prevalence of allelic imbalance at 5 microsatellite polymorphic markers on chromosomes 7q31-35, 8p12-21, 8p22, 8q22.2, and 18q12.2 from 15 patients with AAH. DNA samples were obtained from formalin-fixed paraffin-embedded sections using tissue microdissection. We found allelic imbalance in 7 of 15 (47%) cases of AAH. Genetic changes that commonly occur in early prostatic carcinogenesis and prostate carcinoma are found in AAH. Current data provide evidence of a genetic link between some cases of AAH and carcinoma.
Original language | English (US) |
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Pages (from-to) | 389-391 |
Number of pages | 3 |
Journal | Cancer research |
Volume | 58 |
Issue number | 3 |
State | Published - Feb 1 1998 |
ASJC Scopus subject areas
- Oncology
- Cancer Research