Atrial natriuretic peptide in hypothyroidism

R. S. Zimmerman, H. Gharib, D. Zimmerman, D. Heublein, J. C. Burnett

Research output: Contribution to journalArticlepeer-review

47 Scopus citations


The effect of hypothyroidism on circulating levels of atrial natriuretic peptide (ANP) was studied in 11 hypothyroid patients (aged 11–65 yr; mean, 31 yr) and 13 normal subjects (aged 28–39 yr; mean, 32 yr). Plasma ANP was 32 ± 9 (±sd) pg/ml in normal subjects and 20 ± 5 pg/ml in the hypothyroid patients (P < 0.005). In 7 hypothyroid patients, plasma ANP levels were measured after 10–14 weeks of l-T4 therapy. ANP increased from 22 ± 5 to 46 ± 18 pg/ml (P < 0.02), along with an increase in mean serum T4 from 0.6 ± 0.5 to 8.1 ± 2.5 μg/dl (P < 0.001). Thus, hypothyroidism is characterized by decreased circulating levels of ANP which are reversed by l-T4 therapy.

Original languageEnglish (US)
Pages (from-to)353-355
Number of pages3
JournalJournal of Clinical Endocrinology and Metabolism
Issue number2
StatePublished - Feb 1987

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical


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