DNase-seq footprinting provides a means to predict genome-wide binding sites for hundreds of transcription factors (TFs) simultaneously. Funk et al. analyze data from the ENCODE consortium to create a resource of footprints in 27 human tissues, demonstrating associations of tissue-specific TF occupancy with gene regulation and disease risk.
- gene regulation
- psychiatric genetics
- transcription factors
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)