TY - JOUR
T1 - Associations of Pulmonary Function with MRI Brain Volumes
T2 - A Coordinated Multi-Study Analysis
AU - Frenzel, Stefan
AU - Bis, Joshua C.
AU - Gudmundsson, Elias F.
AU - O'donnell, Adrienne
AU - Simino, Jeannette
AU - Yaqub, Amber
AU - Bartz, Traci M.
AU - Brusselle, Guy G.O.
AU - Bülow, Robin
AU - Decarli, Charles S.
AU - Ewert, Ralf
AU - Gharib, Sina A.
AU - Ghosh, Saptaparni
AU - Gireud-Goss, Monica
AU - Gottesman, Rebecca F.
AU - Ikram, M. Arfan
AU - Knopman, David S.
AU - Launer, Lenore J.
AU - London, Stephanie J.
AU - Longstreth, W. T.
AU - Lopez, Oscar L.
AU - Melo Van Lent, Debora
AU - O'connor, George
AU - Satizabal, Claudia L.
AU - Shrestha, Srishti
AU - Sigurdsson, Sigurdur
AU - Stubbe, Beate
AU - Talluri, Rajesh
AU - Vasan, Ramachandran S.
AU - Vernooij, Meike W.
AU - Völzke, Henry
AU - Wiggins, Kerri L.
AU - Yu, Bing
AU - Beiser, Alexa S.
AU - Gudnason, Vilmundur
AU - Mosley, Thomas
AU - Psaty, Bruce M.
AU - Wolters, Frank J.
AU - Grabe, Hans J.
AU - Seshadri, Sudha
N1 - Funding Information:
This study was supported by National Institute of Health (NIH) grant AG059421. Additional study-specific acknowledgements can be found in the Supplementary Material.
Publisher Copyright:
© 2022 - The authors. Published by IOS Press.
PY - 2022
Y1 - 2022
N2 - Background: Previous studies suggest poor pulmonary function is associated with increased burden of cerebral white matter hyperintensities and brain atrophy among elderly individuals, but the results are inconsistent. Objective: To study the cross-sectional associations of pulmonary function with structural brain variables. Methods: Data from six large community-based samples (N = 11,091) were analyzed. Spirometric measurements were standardized with respect to age, sex, height, and ethnicity using reference equations of the Global Lung Function Initiative. Associations of forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and their ratio FEV1/FVC with brain volume, gray matter volume, hippocampal volume, and volume of white matter hyperintensities were investigated using multivariable linear regressions for each study separately and then combined using random-effect meta-analyses. Results: FEV1 and FVC were positively associated with brain volume, gray matter volume, and hippocampal volume, and negatively associated with white matter hyperintensities volume after multiple testing correction, with little heterogeneity present between the studies. For instance, an increase of FVC by one unit was associated with 3.5 ml higher brain volume (95% CI: [2.2, 4.9]). In contrast, results for FEV1/FVC were more heterogeneous across studies, with significant positive associations with brain volume, gray matter volume, and hippocampal volume, but not white matter hyperintensities volume. Associations of brain variables with both FEV1 and FVC were consistently stronger than with FEV1/FVC, specifically with brain volume and white matter hyperintensities volume. Conclusion: In cross-sectional analyses, worse pulmonary function is associated with smaller brain volumes and higher white matter hyperintensities burden.
AB - Background: Previous studies suggest poor pulmonary function is associated with increased burden of cerebral white matter hyperintensities and brain atrophy among elderly individuals, but the results are inconsistent. Objective: To study the cross-sectional associations of pulmonary function with structural brain variables. Methods: Data from six large community-based samples (N = 11,091) were analyzed. Spirometric measurements were standardized with respect to age, sex, height, and ethnicity using reference equations of the Global Lung Function Initiative. Associations of forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and their ratio FEV1/FVC with brain volume, gray matter volume, hippocampal volume, and volume of white matter hyperintensities were investigated using multivariable linear regressions for each study separately and then combined using random-effect meta-analyses. Results: FEV1 and FVC were positively associated with brain volume, gray matter volume, and hippocampal volume, and negatively associated with white matter hyperintensities volume after multiple testing correction, with little heterogeneity present between the studies. For instance, an increase of FVC by one unit was associated with 3.5 ml higher brain volume (95% CI: [2.2, 4.9]). In contrast, results for FEV1/FVC were more heterogeneous across studies, with significant positive associations with brain volume, gray matter volume, and hippocampal volume, but not white matter hyperintensities volume. Associations of brain variables with both FEV1 and FVC were consistently stronger than with FEV1/FVC, specifically with brain volume and white matter hyperintensities volume. Conclusion: In cross-sectional analyses, worse pulmonary function is associated with smaller brain volumes and higher white matter hyperintensities burden.
KW - Dementia
KW - epidemiology
KW - magnetic resonance imaging
KW - respiratory function tests
UR - http://www.scopus.com/inward/record.url?scp=85142940876&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85142940876&partnerID=8YFLogxK
U2 - 10.3233/JAD-220667
DO - 10.3233/JAD-220667
M3 - Article
C2 - 36213999
AN - SCOPUS:85142940876
SN - 1387-2877
VL - 90
SP - 1073
EP - 1083
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
IS - 3
ER -