TY - JOUR
T1 - Associations between polymorphisms in the antiviral TRIM genes and measles vaccine immunity
AU - Ovsyannikova, Inna G.
AU - Haralambieva, Iana H.
AU - Vierkant, Robert A.
AU - O'Byrne, Megan M.
AU - Poland, Gregory A.
N1 - Funding Information:
We thank the Mayo Clinic Vaccine Research Group staff and subjects who participated in our studies. We thank Caroline L. Vitse for her help with this manuscript. This work was supported by NIH grants AI33144 , AI48793 (which recently received a MERIT Award), and was made possible by the Rochester Epidemiology Project (Grant Number R01 AG034676 from the National Institute on Aging ).
PY - 2013/6
Y1 - 2013/6
N2 - The role of polymorphisms within the antiviral tripartite motif (TRIM) genes in measles vaccine adaptive immune responses was examined. A limited association was found between TRIM5 (rs7122620) and TRIM25 (rs205499) gene polymorphisms and measles-specific antibody levels. However, many associations were found between TRIM gene SNPs and variations in cellular responses (IFN-γ Elispot and secreted cytokines IL-2, IL-6, IL-10, IFN-γ, and TNF-α). TRIM22 rs2291841 was significantly associated with an increased IFN-γ Elispot response (35 vs. 102 SFC per 2×105PBMC, p=0.009, q=0.71) in Caucasians. A non-synonymous TRIM25 rs205498 (in LD with other SNPs, r20.56), as well as the TRIM25 AAAGGAAAGGAGT haplotype, was associated with a decreased IFN-γ Elispot response (t-statistic -2.32, p=0.02) in African-Americans. We also identified polymorphisms in the TRIM5, TRIM22, and TRIM25 genes that were associated with significant differences in cytokine responses. Additional studies are necessary to replicate our findings and to examine the functional consequences of these associations.
AB - The role of polymorphisms within the antiviral tripartite motif (TRIM) genes in measles vaccine adaptive immune responses was examined. A limited association was found between TRIM5 (rs7122620) and TRIM25 (rs205499) gene polymorphisms and measles-specific antibody levels. However, many associations were found between TRIM gene SNPs and variations in cellular responses (IFN-γ Elispot and secreted cytokines IL-2, IL-6, IL-10, IFN-γ, and TNF-α). TRIM22 rs2291841 was significantly associated with an increased IFN-γ Elispot response (35 vs. 102 SFC per 2×105PBMC, p=0.009, q=0.71) in Caucasians. A non-synonymous TRIM25 rs205498 (in LD with other SNPs, r20.56), as well as the TRIM25 AAAGGAAAGGAGT haplotype, was associated with a decreased IFN-γ Elispot response (t-statistic -2.32, p=0.02) in African-Americans. We also identified polymorphisms in the TRIM5, TRIM22, and TRIM25 genes that were associated with significant differences in cytokine responses. Additional studies are necessary to replicate our findings and to examine the functional consequences of these associations.
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U2 - 10.1016/j.humimm.2013.01.031
DO - 10.1016/j.humimm.2013.01.031
M3 - Article
C2 - 23416095
AN - SCOPUS:84877071781
SN - 0198-8859
VL - 74
SP - 768
EP - 774
JO - Human Immunology
JF - Human Immunology
IS - 6
ER -