Abstract
We studied the putative association of a C→T polymorphism in exon-5 of IL-1β and an 85 bp tandem repeat in intron-4 of IL-1 receptor antagonist (IL-1ra) genes with susceptibility to or outcome of MS. DNA from 122 cases from a population-based cohort in Olmsted County, MN who were previously categorized for disease severity and temporal course and 244 ethnically- matched controls were analyzed. There was no association between either polymorphism and disease susceptibility. Allele-2 of IL-1β and allele-3 of the IL-1ra polymorphisms were associated with a favorable outcome (P=0.023 and P=0.030). (C) 2000 Elsevier Science B.V.
Original language | English (US) |
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Pages (from-to) | 220-227 |
Number of pages | 8 |
Journal | Journal of neuroimmunology |
Volume | 106 |
Issue number | 1-2 |
DOIs | |
State | Published - Jul 1 2000 |
Keywords
- Genetics
- IL-1 receptor antagonist
- Interleukin-1
- Multiple sclerosis
- Prognosis
- Susceptibility
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Neurology
- Clinical Neurology