@article{9d7ad85c77c04e379e1cb3fe761eda52,
title = "Association of BRAF V600E Status of Incident Melanoma and Risk for a Second Primary Malignancy: A Population-Based Study",
abstract = "Mutations of the BRAF oncogene occur in both melanomas and several other cancers. Our objective was to determine if mutant BRAF V600E expression in a population-based cohort of patients with melanoma was associated with the development of a second primary malignancy of any type. Using the resources of the Rochester Epidemiology Project, we retrospectively identified 380 patients aged 18 to 60 years who were diagnosed with an incident melanoma from 1970 through 2009. We reviewed individual medical records to identify second primary malignancies. We evaluated mutant BRAF V600E expression from available melanoma tissue specimens and assessed its association with the development of a second primary malignancy. BRAF V600E expression in melanomas is associated with an increased risk for basal cell carcinoma (BCC).",
author = "Lalla, {Soogan C.} and Kumar, {Anagha Bangalore} and Lehman, {Julia S.} and Lohse, {Christine M.} and Brewer, {Jerry D}",
note = "Funding Information: From the Mayo Clinic, Rochester, Minnesota. Drs. Lalla and Brewer are from the Department of Dermatology, Dr. Bangalore Kumar is from the Department of Immunology, Dr. Lehman is from the Division of Anatomic Pathology, and Ms. Lohse is from the Division of Biomedical Statistics and Informatics. The authors report no conflict of interest. This study was made possible by using the resources of the Rochester Epidemiology Project, which is supported by the National Institute on Aging of the National Institutes of Health (NIH) under Award Number R01AG034676. BRAF staining of histopathology slides was supported by the Department of Dermatology at the Mayo Clinic, Rochester, Minnesota. Dr. Kumar was supported by the NIH grant T32 GM008685-20. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The funders had no role in study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the article for publication. Correspondence: Jerry D. Brewer, MD, MS, Department of Dermatology, Mayo Clinic, 200 First St SW, Rochester, MN 55905 (Brewer.Jerry@mayo.edu). doi:10.12788/cutis.0607 Publisher Copyright: Copyright Cutis 2022.",
year = "2022",
month = sep,
doi = "10.12788/cutis.0607",
language = "English (US)",
volume = "110",
pages = "150--154",
journal = "Cutis",
issn = "0011-4162",
publisher = "Quadrant Healthcom Inc.",
number = "3",
}