Association of anemia with outcomes of acute heart failure

Ahmad Halawa, M. Caroline Burton, Michael J. Maniaci, Brian P. Shapiro, Daniel S. Yip, David O. Hodge, Emily R. Vargas, Nancy Dawson

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Objectives: Anemia is common in patients presenting with acute congestive heart failure (CHF); when hemoglobin (HGB) declines to low levels, it can result in worse outcomes. The aim of this study was to determine a level of HGB on admission or discharge that affects outcomes in patients with CHF and then to evaluate the effect of the low HGB levels on these outcomes. Methods: We conducted a retrospective cohort study of 756 patients admitted with acute CHF during the period January 1, 2011-December 31, 2014. We used multivariable regression analysis to evaluate the relation among HGB levels and three major outcomes: 3-year mortality, 30-day readmission rate, and length of stay (LOS). Results: Compared with patients with HGB ≥10 g/dL, patients with HGB <10 g/dL on discharge from the hospital had higher mortality (3-year survival 46% vs 33%, P = 0.023) and 30-day readmission rates (23% vs 14%; P = 0.008) and increased LOS (4.8 vs 3.2 days, P < 0.001). Patients with admission HGB <10 g/dL had higher mortality rates (3-year survival 45% vs 32%, P = 0.019) and increased LOS (4.5 vs 3.4 days, P = 0.014). A lower admission HGB value was associated with higher 30-day readmission rates, but it was not statistically significant (P = 0.06). Conclusions: An HGB level <10 g/dL on admission or discharge in patients hospitalized with acute CHF is associated with a significantly worse outcome.

Original languageEnglish (US)
Pages (from-to)103-108
Number of pages6
JournalSouthern medical journal
Issue number2
StatePublished - Feb 1 2018


  • Anemia
  • Congestive heart failure
  • Heart failure outcome

ASJC Scopus subject areas

  • General Medicine


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