TY - JOUR
T1 - Association between HLA haplotypes and increased serum levels of IgG4 in patients with primary sclerosing cholangitis
AU - Berntsen, Natalie L.
AU - Klingenberg, Olav
AU - Juran, Brian D.
AU - Benito De Valle, Maria
AU - Lindkvist, Björn
AU - Lazaridis, Konstantinos N.
AU - Boberg, Kirsten Muri
AU - Karlsen, Tom H.
AU - Hov, Johannes Roksund
N1 - Funding Information:
Funding This study was funded by the Norwegian Primary Sclerosing Cholangitis Research Center, and by National Institutes of Health grant DK 084960 (K.N.L.).
Publisher Copyright:
© 2015 AGA Institute.
PY - 2015/5/1
Y1 - 2015/5/1
N2 - Increased serum levels of IgG4 have been reported in 9%-15% of patients with primary sclerosing cholangitis (PSC); it is not clear whether this increase contributes to pathogenesis. We performed genetic analyses of the HLA complex in patients with PSC from Norway, Sweden, and from the United States. We found an association between levels of IgG4 above the upper reference limit and specific HLA haplotypes. These patients had a significantly lower frequency of the strongest PSC risk factor, HLA-B∗08, than patients without increased IgG4, and significantly higher frequencies of HLA-B∗07 and HLA-DRB1∗15. HLA genotype therefore might affect the serum concentration of IgG4, and increased IgG4 might be a marker of a distinct phenotype of PSC.
AB - Increased serum levels of IgG4 have been reported in 9%-15% of patients with primary sclerosing cholangitis (PSC); it is not clear whether this increase contributes to pathogenesis. We performed genetic analyses of the HLA complex in patients with PSC from Norway, Sweden, and from the United States. We found an association between levels of IgG4 above the upper reference limit and specific HLA haplotypes. These patients had a significantly lower frequency of the strongest PSC risk factor, HLA-B∗08, than patients without increased IgG4, and significantly higher frequencies of HLA-B∗07 and HLA-DRB1∗15. HLA genotype therefore might affect the serum concentration of IgG4, and increased IgG4 might be a marker of a distinct phenotype of PSC.
KW - Genetic Association Study
KW - IgG4-Associated Cholangitis
KW - Immune Response
KW - Immunogenetics
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U2 - 10.1053/j.gastro.2015.01.041
DO - 10.1053/j.gastro.2015.01.041
M3 - Article
C2 - 25655558
AN - SCOPUS:84928625736
SN - 0016-5085
VL - 148
SP - 924-927.e2
JO - Gastroenterology
JF - Gastroenterology
IS - 5
ER -