TY - JOUR
T1 - Association Between Food Intake and Gastrointestinal Symptoms in Patients With Obesity
AU - Ghusn, Wissam
AU - Cifuentes, Lizeth
AU - Campos, Alejandro
AU - Sacoto, Daniel
AU - De La Rosa, Alan
AU - Feris, Fauzi
AU - Calderon, Gerardo
AU - Gonzalez-Izundegui, Daniel
AU - Stutzman, Jessica
AU - Hurtado, Maria Daniela
AU - Camilleri, Michael
AU - Acosta, Andres
N1 - Publisher Copyright:
© 2023 The Authors
PY - 2023/1
Y1 - 2023/1
N2 - Background and Aims: Hunger, satiation, postprandial satiety, and hedonic eating constitute key food intake parameters. We aim to study whether these symptoms are associated with gastrointestinal symptoms (GIS) in patients with obesity. Methods: This is a cross-sectional study of patients with obesity. Patients completed the following validated biomarkers and questionnaires: hunger was measured via visual analog scale (100 mm) following a standard meal, satiation was measured via ad libitum meal (calories to fullness; kcal), postprandial satiety was measured via gastric emptying scintigraphy (T1/2; mins), and hedonic eating was measured via the Hospital Anxiety and Depression Scale questionnaire. Participants completed the abridged Bowel Disease Questionnaire to evaluate their GIS. We calculated the odds ratios (ORs) adjusted for sex, weight, and age between food intake parameters <25th or >75th percentile observed in a prior cohort of 450 participants with obesity and GIS. Results: A total of 274 participants (41 ± 10 [SD] years, 75% females, body mass index 39 ± 8 kg/m2) were included in the analysis. Increased hunger was associated with a lower prevalence of lumpy stools (OR = 0.18, P =.02). Satiation was associated with abdominal pain/discomfort (relieved by defecation [OR = 2.4, P =.02] or associated with change in stool consistency [OR = 2.92, P <.01]), loose/watery stools (OR = 2.09, P =.02), and bloating (OR = 2.49, P <.01). Abnormal postprandial satiety was associated with bloating (OR = 2.26, P <.01) and loose/watery stools (OR = 1.84, P =.04). Hedonic eating was associated with abdominal pain/discomfort with stool frequency change (OR = 2.4, P =.02), >3 bowel movements per day (OR = 1.93, P =.048), bloating (OR = 2.49, P =.01), abdominal pain after meals >1 per month (OR = 4.24, P <.01), and nausea >1 per week (OR = 4.51, P <.01). Conclusion: Alterations in hunger, satiation, postprandial satiety, and hedonic eating are associated with GIS in patients with obesity.
AB - Background and Aims: Hunger, satiation, postprandial satiety, and hedonic eating constitute key food intake parameters. We aim to study whether these symptoms are associated with gastrointestinal symptoms (GIS) in patients with obesity. Methods: This is a cross-sectional study of patients with obesity. Patients completed the following validated biomarkers and questionnaires: hunger was measured via visual analog scale (100 mm) following a standard meal, satiation was measured via ad libitum meal (calories to fullness; kcal), postprandial satiety was measured via gastric emptying scintigraphy (T1/2; mins), and hedonic eating was measured via the Hospital Anxiety and Depression Scale questionnaire. Participants completed the abridged Bowel Disease Questionnaire to evaluate their GIS. We calculated the odds ratios (ORs) adjusted for sex, weight, and age between food intake parameters <25th or >75th percentile observed in a prior cohort of 450 participants with obesity and GIS. Results: A total of 274 participants (41 ± 10 [SD] years, 75% females, body mass index 39 ± 8 kg/m2) were included in the analysis. Increased hunger was associated with a lower prevalence of lumpy stools (OR = 0.18, P =.02). Satiation was associated with abdominal pain/discomfort (relieved by defecation [OR = 2.4, P =.02] or associated with change in stool consistency [OR = 2.92, P <.01]), loose/watery stools (OR = 2.09, P =.02), and bloating (OR = 2.49, P <.01). Abnormal postprandial satiety was associated with bloating (OR = 2.26, P <.01) and loose/watery stools (OR = 1.84, P =.04). Hedonic eating was associated with abdominal pain/discomfort with stool frequency change (OR = 2.4, P =.02), >3 bowel movements per day (OR = 1.93, P =.048), bloating (OR = 2.49, P =.01), abdominal pain after meals >1 per month (OR = 4.24, P <.01), and nausea >1 per week (OR = 4.51, P <.01). Conclusion: Alterations in hunger, satiation, postprandial satiety, and hedonic eating are associated with GIS in patients with obesity.
KW - Hedonic Eating
KW - Hunger
KW - Obesity
KW - Postprandial Satiety
KW - Satiation
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U2 - 10.1016/j.gastha.2022.07.019
DO - 10.1016/j.gastha.2022.07.019
M3 - Article
AN - SCOPUS:85173972921
SN - 2772-5723
VL - 2
SP - 121
EP - 128
JO - Gastro Hep Advances
JF - Gastro Hep Advances
IS - 1
ER -