TY - JOUR
T1 - Assessment of Thoracic Blood Volume by Computerized Tomography in Patients With Heart Failure and Periodic Breathing
AU - Jorgenson, Caitlin C.
AU - Chase, Steven C.
AU - Olson, Lyle J.
AU - Johnson, Bruce D.
N1 - Funding Information:
Funding: This study was funded by NIH Grant HL71478 and the Mayo Clinic Graduate School of Biomedical Sciences.
Funding Information:
Funding: This study was funded by NIH Grant HL71478 and the Mayo Clinic Graduate School of Biomedical Sciences .
Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2018/7
Y1 - 2018/7
N2 - Background: Periodic breathing (PB) is often observed in patients with HF at rest, with sleep and during exercise. However, mechanisms underlying abnormal ventilatory control are not entirely established. Methods: Eleven subjects with HF (10 males, age = 69 ± 12 y) and 12 age-matched control subjects (8 males, age = 65 ± 9 y) participated in the study. PB was defined as a peak in the 0.003–0.04 Hz frequency range of the flow signal during 6 minutes of awake resting breathing. Thoracic blood volumes (V t , thorax; V h , heart; V p , pulmonary), mean transit times (MTTs), and extravascular lung water (EVLW) were quantified using computerized tomography. Results: PB was observed in 7 subjects with HF and was associated with worse functional status. The HF PB-present group had thoracic blood volumes nearly double those of control and HF PB-absent subjects (volumes reported as mL/m 2 body surface area, P values vs control: control = 813 ± 246, HF PB-absent = 822 ± 161 P =.981, HF PB-present = 1579 ± 548 P =.002). PB was associated with longer pulmonary MTT (control = 6.7 ± 1.2 s, HF PB-absent = 6.0 ± 0.8 s, HF PB-present = 8.4 ± 1.6 s; P =.033, HF PB-present vs HF PB-absent). EVLW was not elevated in the PB group. Conclusions: Subjects with HF and PB at rest have greater centralization of blood volume.
AB - Background: Periodic breathing (PB) is often observed in patients with HF at rest, with sleep and during exercise. However, mechanisms underlying abnormal ventilatory control are not entirely established. Methods: Eleven subjects with HF (10 males, age = 69 ± 12 y) and 12 age-matched control subjects (8 males, age = 65 ± 9 y) participated in the study. PB was defined as a peak in the 0.003–0.04 Hz frequency range of the flow signal during 6 minutes of awake resting breathing. Thoracic blood volumes (V t , thorax; V h , heart; V p , pulmonary), mean transit times (MTTs), and extravascular lung water (EVLW) were quantified using computerized tomography. Results: PB was observed in 7 subjects with HF and was associated with worse functional status. The HF PB-present group had thoracic blood volumes nearly double those of control and HF PB-absent subjects (volumes reported as mL/m 2 body surface area, P values vs control: control = 813 ± 246, HF PB-absent = 822 ± 161 P =.981, HF PB-present = 1579 ± 548 P =.002). PB was associated with longer pulmonary MTT (control = 6.7 ± 1.2 s, HF PB-absent = 6.0 ± 0.8 s, HF PB-present = 8.4 ± 1.6 s; P =.033, HF PB-present vs HF PB-absent). EVLW was not elevated in the PB group. Conclusions: Subjects with HF and PB at rest have greater centralization of blood volume.
KW - Thoracic fluid volumes
KW - extravascular lung water
KW - mean transit time
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U2 - 10.1016/j.cardfail.2018.04.004
DO - 10.1016/j.cardfail.2018.04.004
M3 - Article
C2 - 29678727
AN - SCOPUS:85047179566
SN - 1071-9164
VL - 24
SP - 479
EP - 483
JO - Journal of Cardiac Failure
JF - Journal of Cardiac Failure
IS - 7
ER -