Assessment of abnormal liver injury tests

Mashal Jatoi Batheja, Hugo E. Vargas

Research output: Chapter in Book/Report/Conference proceedingChapter


Evidence of hepatic injury on routine biochemical evaluation should prompt a rapid decision-making process in the clinician. Elevations of hepatocellular injury tests (aspartate transaminase or AST, alanine transaminase or ALT) should be evaluated with an eye to the relative magnitude, pace of elevation, and relative increase over other markers. In this way, appropriate resources can be devoted to rapid evaluation. Increases in cholestatic injury tests (alkaline phosphatase liver fraction, γ-glutamyl transpeptidase, and bilirubin) should prompt assessment of biliary tree anatomy and consideration of autoimmune, metabolic, or toxic injury of the liver. Finally, the liver 's ability to synthesize factors such as albumin and factor V is a very quick gauge of the extent of the liver injury.

Original languageEnglish (US)
Title of host publicationPractical Gastroenterology and Hepatology
Subtitle of host publicationLiver and Biliary Disease
Number of pages6
ISBN (Electronic)9781444325249
ISBN (Print)9781405182751
StatePublished - Aug 31 2010

ASJC Scopus subject areas

  • General Medicine


Dive into the research topics of 'Assessment of abnormal liver injury tests'. Together they form a unique fingerprint.

Cite this