Arterial Stiffness Estimation by Shear Wave Elastography: Validation in Phantoms with Mechanical Testing

Elira Maksuti, Erik Widman, David Larsson, Matthew W. Urban, Matilda Larsson, Anna Bjällmark

Research output: Contribution to journalArticlepeer-review

52 Scopus citations


Arterial stiffness is an independent risk factor found to correlate with a wide range of cardiovascular diseases. It has been suggested that shear wave elastography (SWE) can be used to quantitatively measure local arterial shear modulus, but an accuracy assessment of the technique for arterial applications has not yet been performed. In this study, the influence of confined geometry on shear modulus estimation, by both group and phase velocity analysis, was assessed, and the accuracy of SWE in comparison with mechanical testing was measured in nine pressurized arterial phantoms. The results indicated that group velocity with an infinite medium assumption estimated shear modulus values incorrectly in comparison with mechanical testing in arterial phantoms (6.7 ± 0.0 kPa from group velocity and 30.5 ± 0.4 kPa from mechanical testing). To the contrary, SWE measurements based on phase velocity analysis (30.6 ± 3.2 kPa) were in good agreement with mechanical testing, with a relative error between the two techniques of 8.8 ± 6.0% in the shear modulus range evaluated (40–100 kPa). SWE by phase velocity analysis was validated to accurately measure stiffness in arterial phantoms.

Original languageEnglish (US)
Pages (from-to)308-321
Number of pages14
JournalUltrasound in Medicine and Biology
Issue number1
StatePublished - Jan 1 2016


  • Accuracy
  • Arterial phantom
  • Arterial stiffness
  • Group velocity
  • Lamb waves
  • Mechanical testing
  • Phase velocity
  • Poly(vinyl alcohol)
  • Shear modulus
  • Shear wave elastography

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Biophysics
  • Acoustics and Ultrasonics


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