Are phosphatonins relevant in the pathogenesis of nephrolithiasis?

Aisha Shaikh, Rajiv Kumar

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Hypercalciuria is the single most important risk factor for stone disease and renal phosphate excretion is a recognized cause of absorptive hypercalciuria. The recent identification of "phosphatonins" that increase renal phosphate excretion has raised the possibility that these factors might be responsible for the phosphaturia seen in some patients with absorptive hypercalciuria. It is important to recognize that both parathyroid hormone and phosphatonins are phosphaturic, but they have opposite effects on 1,25(OH) 2D3 regulation. Serum concentrations of fibroblast growth factor-23, one of the phosphatonins, have been shown to be increased in some stone formers suggesting a pathogenic role. Future studies are needed to define the exact role of phosphatonins in nephrolithiasis.

Original languageEnglish (US)
Title of host publicationRENAL STONE DISEASE
Subtitle of host publication1st Annual International Urolithiasis Research Symposium
PublisherAmerican Institute of Physics Inc.
Number of pages6
ISBN (Print)0735404062, 9780735404069
StatePublished - 2007
Event1st Annual International Urolithiasis Research Symposium - Indianapolis, IN, United States
Duration: Nov 2 2006Nov 3 2006

Publication series

NameAIP Conference Proceedings
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616


Other1st Annual International Urolithiasis Research Symposium
Country/TerritoryUnited States
CityIndianapolis, IN


  • Nephrolithiasis
  • Phosphatonins and fibroblast growth factor-23

ASJC Scopus subject areas

  • General Physics and Astronomy


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