Aprotinin for coronary artery bypass grafting: Effect on postoperative renal function

John H. Lemmer, William Stanford, Sharon L. Bonney, Eva V. Chomka, Robert B. Karp, Glenn W. Laub, John A. Rumberger, Hartzell V. Schaff

Research output: Contribution to journalArticlepeer-review

78 Scopus citations


Two hundred sixteen patients undergoing coronary artery bypass graft procedures were randomized to receive either high-dose aprotinin or placebo. Clinically important postoperative renal insufficiency was infrequent, with a single patient (0.9%) from each group requiring dialysis. Although increases in the serum creatinine level occurred postoperatively in more patients who received aprotinin (20/108) than in those given placebo (13/108), the difference between the two group was not statistically significant (p = 0.186), and the increases were generally small and transient. Likewise, there was no difference between the groups in terms of the incidence of abnormal serum electrolyte levels, blood era nitrogen levels, or urinalysis findings, or in the frequency of abnormal creatinine clearance rates. Under the conditions described, aprotinin use does not appear to be associated with a significant risk of serious renal toxicity.

Original languageEnglish (US)
Pages (from-to)132-136
Number of pages5
JournalThe Annals of thoracic surgery
Issue number1
StatePublished - Jan 1995

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine


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