Appetite and obesity: A gastroenterologist's perspective

M. Camilleri, A. B.M. Grudell

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations


This review focuses on the gastrointestinal tract's control of appetite and interventions directed to the gut that are effective in the treatment of obesity. It examines the evidence linking gut hormones to the control of both appetite and upper gastrointestinal motility, the evidence that stomach function is altered and contributes to satiation in obesity and outlines the principles of therapy for obesity which are directed at the gastrointestinal tract. These therapies impair fat absorption or alter stomach functions through pharmacological, device, endoscopic, or surgical approaches. Gastroenterologists need to understand the role of factors controlling appetite in order to effectively manage the increasing number of obese patients and the ways the gut function may be altered as a result of the treatments and their complications.

Original languageEnglish (US)
Pages (from-to)333-341
Number of pages9
JournalNeurogastroenterology and Motility
Issue number5
StatePublished - May 2007


  • Appetite
  • Gastric emptying
  • Gastric volume
  • Obesity

ASJC Scopus subject areas

  • Physiology
  • Endocrine and Autonomic Systems
  • Gastroenterology


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