Apolipoprotein e and LRP1 increase early in Parkinson's disease pathogenesis

Micha M.M. Wilhelmus, John G.J.M. Bol, Elise S. Van Haastert, Annemieke J.M. Rozemuller, Guojun Bu, Benjamin Drukarch, Jeroen J.M. Hoozemans

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Parkinson's disease (PD) is characterized by α-synucleincontaining Lewy bodies (LBs) and loss of melanized neurons in the substantia nigra (SN). Recently, a link between apolipoprotein E (ApoE) expression, α-synuclein aggregation, and neurodegeneration was suggested. Here, we report on ApoE expression appearing in melanized neurons of the SN and in LBs in both PD and incidental LB disease cases. Interestingly, increased expression of the low-density lipoprotein receptor-related protein 1 (the receptor for ApoE) was also observed in incidental LB disease and PD. Our data suggest that alterations in lipoprotein homeostasis/signaling in melanized neurons of the SN are an early event during PD pathogenesis.

Original languageEnglish (US)
Pages (from-to)2152-2156
Number of pages5
JournalAmerican Journal of Pathology
Issue number5
StatePublished - Nov 2011

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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