TY - JOUR
T1 - Apolipoprotein e and its receptors in Alzheimer's disease
T2 - Pathways, pathogenesis and therapy
AU - Bu, Guojun
N1 - Funding Information:
The author wishes to thank P. Tarr, D. owyoung and members of the Bu laboratory for critical reading and comments on this Review. He apologizes to those whose work is not cited owing to either space limitations or the specific focus of the Review. Work in the author’s laboratory is supported by the US National Institutes of Health (grants R01AG027924 and R01AG031784) and a Zenith Fellows Award from the Alzheimer’s Association.
PY - 2009/5
Y1 - 2009/5
N2 - The vast majority of Alzheimer's disease (AD) cases are late-onset and their development is probably influenced by both genetic and environmental risk factors. A strong genetic risk factor for late-onset AD is the presence of the 4 allele of the apolipoprotein E (APOE) gene, which encodes a protein with crucial roles in cholesterol metabolism. There is mounting evidence that APOE4 contributes to AD pathogenesis by modulating the metabolism and aggregation of amyloid-Β peptide and by directly regulating brain lipid metabolism and synaptic functions through APOE receptors. Emerging knowledge of the contribution of APOE to the pathophysiology of AD presents new opportunities for AD therapy.
AB - The vast majority of Alzheimer's disease (AD) cases are late-onset and their development is probably influenced by both genetic and environmental risk factors. A strong genetic risk factor for late-onset AD is the presence of the 4 allele of the apolipoprotein E (APOE) gene, which encodes a protein with crucial roles in cholesterol metabolism. There is mounting evidence that APOE4 contributes to AD pathogenesis by modulating the metabolism and aggregation of amyloid-Β peptide and by directly regulating brain lipid metabolism and synaptic functions through APOE receptors. Emerging knowledge of the contribution of APOE to the pathophysiology of AD presents new opportunities for AD therapy.
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U2 - 10.1038/nrn2620
DO - 10.1038/nrn2620
M3 - Review article
C2 - 19339974
AN - SCOPUS:67349270965
SN - 1471-003X
VL - 10
SP - 333
EP - 344
JO - Nature Reviews Neuroscience
JF - Nature Reviews Neuroscience
IS - 5
ER -