TY - JOUR
T1 - Apolipoprotein ∈4 allele frequency in young Africans of Ugandan descent versus African Americans
AU - Willis, Floyd
AU - Graff-Radford, Neill
AU - Pinto, Martin
AU - Lawson, La Shaune
AU - Adamson, Jennifer
AU - Epstein, Dawn
AU - Parfitt, Francine
AU - Hutton, Mike
AU - O'Brien, Peter C.
PY - 2003/1/1
Y1 - 2003/1/1
N2 - Through its role in lipid metabolism, Apolipoprotein ∈4 (ApoE4) may affect "brain repair" in stroke, brain hemorrhage, Alzheimer's disease, and other brain injury syndromes for which African Americans may have greater morbidity and mortality. Cross-cultural evaluations of these and other genetic factors may provide insight on possible ethnic differences in risk of morbidity to acute central nervous system (CNS) injury and chronic neurodegenerative processes. As an initial step toward expanding knowledge of ApoE allele frequencies for persons of African descent, we compared ApoE genotype of a group of 70 young Ugandans to 59 (subset of a larger group of 342 African Americans of all ages) age-matched African Americans and to published frequencies for Caucasians and Asians. We found that the ApoE4 and ∈2 alleles are more frequent in Ugandans (U) than Caucasians (C) or Asians (A) with corresponding alleles showing significant elevations of ∈2 (U 15.71%, C 8.40%, A 4.20%) and Î4 (U 25%, C 13.70%, A 8.90%) (p < .001). Comparing the differences between Ugandans and age-appropriate African Americans (AA) was not statically significant, but this outcome may be due to small sample size. These results provide the only published ApoE frequencies for Ugandans and the complete set of data provides the largest published community group of ApoE frequencies for African Americans.
AB - Through its role in lipid metabolism, Apolipoprotein ∈4 (ApoE4) may affect "brain repair" in stroke, brain hemorrhage, Alzheimer's disease, and other brain injury syndromes for which African Americans may have greater morbidity and mortality. Cross-cultural evaluations of these and other genetic factors may provide insight on possible ethnic differences in risk of morbidity to acute central nervous system (CNS) injury and chronic neurodegenerative processes. As an initial step toward expanding knowledge of ApoE allele frequencies for persons of African descent, we compared ApoE genotype of a group of 70 young Ugandans to 59 (subset of a larger group of 342 African Americans of all ages) age-matched African Americans and to published frequencies for Caucasians and Asians. We found that the ApoE4 and ∈2 alleles are more frequent in Ugandans (U) than Caucasians (C) or Asians (A) with corresponding alleles showing significant elevations of ∈2 (U 15.71%, C 8.40%, A 4.20%) and Î4 (U 25%, C 13.70%, A 8.90%) (p < .001). Comparing the differences between Ugandans and age-appropriate African Americans (AA) was not statically significant, but this outcome may be due to small sample size. These results provide the only published ApoE frequencies for Ugandans and the complete set of data provides the largest published community group of ApoE frequencies for African Americans.
KW - Alzheimer's disease
KW - Apolipoprotein ∈
UR - http://www.scopus.com/inward/record.url?scp=0037271575&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037271575&partnerID=8YFLogxK
M3 - Review article
C2 - 12656452
AN - SCOPUS:0037271575
SN - 0027-9684
VL - 95
SP - 71
EP - 76
JO - Journal of the National Medical Association
JF - Journal of the National Medical Association
IS - 1
ER -