APOE interacts with age to modify rate of decline in cognitive and brain changes in Alzheimer's disease

Yu Ling Chang, Christine Fennema-Notestine, Dominic Holland, Linda K. McEvoy, Nikki H. Stricker, David P. Salmon, Anders M. Dale, Mark W. Bondi

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Objective To determine (1) whether age-standardized cognitive declines and brain morphometric change differ between Young-Old patients with Alzheimer's disease (YOAD) and Very-Old patients with Alzheimer's disease (VOAD), and (2) whether the apolipoprotein E (APOE) genotype modifies these neuropsychological and morphometric changes. Methods Baseline and 12-month follow-up neuropsychological and morphometric measures were examined for healthy control subjects and patients with AD. The two AD groups were divided further into subgroups on the basis of the presence of at least one APOE ε4 allele. Results The YOAD group showed more severe deficits and steeper declines in cognition than the VOAD group. Moreover, the presence of an APOE ε4 allele had a more deleterious effect on the YOAD group than the VOAD group on cognition and brain structure both cross-sectionally and longitudinally. Conclusions Results underscore the importance of integrating an individual's age and genetic susceptibility - and their interaction - when examining neuropsychological and neuroimaging changes in the early stages of Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)336-348
Number of pages13
JournalAlzheimer's and Dementia
Issue number3
StatePublished - May 2014


  • APOE genotype
  • Alzheimer's disease
  • Cognition
  • Longitudinal
  • Magnetic resonance imaging
  • Morphometry

ASJC Scopus subject areas

  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience
  • Health Policy
  • Developmental Neuroscience
  • Epidemiology


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