APOE and neuroenergetics: An emerging paradigm in Alzheimer's disease

Andrew B. Wolf, Richard J. Caselli, Eric M. Reiman, Jon Valla

Research output: Contribution to journalReview articlepeer-review

44 Scopus citations


APOE is the major known genetic risk factor for late-onset Alzheimer's disease. Though relationships between APOE-encoded apolipoprotein E and β-amyloid are increasingly well described, mounting evidence supports wide-ranging effects of APOE on the brain. Specifically, APOE appears to affect brain network activity and closely related neuroenergetic functions that might be involved in vulnerability to neurodegenerative pathophysiology. These effects highlight the salience of further investigation into the diverse influences of APOE. Therefore, this article reviews the interplay between APOE and neuroenergetics and proposes areas for further investigation. This research might lead to the identification of novel therapeutic targets for the treatment and/or prevention of Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)1007-1017
Number of pages11
JournalNeurobiology of aging
Issue number4
StatePublished - Apr 2013


  • APOE
  • Alzheimer's disease
  • Apolipoprotein E
  • Biomarkers
  • Brain imaging
  • Cytochrome oxidase
  • Energy metabolism
  • FMRI
  • Mitochondria
  • Neurodegeneration
  • Neuroenergetics

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology


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