TY - JOUR
T1 - Aortic stenosis in women
AU - Shan, Ying
AU - Pellikka, Patricia A.
N1 - Funding Information:
Funding PAP is supported as the Betty Knight Scripps Professor of Clinical Cardiology Research. YS was supported by a scholarship from Huashan Hospital Fudan University.
Publisher Copyright:
© Author(s) (or their employer(s)) 2020.
PY - 2020/7/1
Y1 - 2020/7/1
N2 - Aortic stenosis (AS) is a common valve disorder in an ageing population in western countries, and women, with longer life expectancy, comprise a substantial percentage of elderly patients with AS. Compared with men, women exhibit distinctive characteristics at the level of stenotic valve leaflets and subsequent compensatory responses of the left ventricle to chronic pressure overload, and in clinical presentation, consequences and response to intervention. Randomised controlled trials of transcatheter aortic valve implantation have yielded new evidence of sex differences in both short-term and long-term outcomes after intervention. A comprehensive knowledge of the existing evidence may inform our understanding of gender differences during assessment and treatment of patients with AS. In this paper, we review the available evidence regarding sex differences in AS in terms of symptoms, clinical presentation, anatomical differences and pathophysiological progression, management and outcomes after aortic valve replacement. Implications for further research are suggested.
AB - Aortic stenosis (AS) is a common valve disorder in an ageing population in western countries, and women, with longer life expectancy, comprise a substantial percentage of elderly patients with AS. Compared with men, women exhibit distinctive characteristics at the level of stenotic valve leaflets and subsequent compensatory responses of the left ventricle to chronic pressure overload, and in clinical presentation, consequences and response to intervention. Randomised controlled trials of transcatheter aortic valve implantation have yielded new evidence of sex differences in both short-term and long-term outcomes after intervention. A comprehensive knowledge of the existing evidence may inform our understanding of gender differences during assessment and treatment of patients with AS. In this paper, we review the available evidence regarding sex differences in AS in terms of symptoms, clinical presentation, anatomical differences and pathophysiological progression, management and outcomes after aortic valve replacement. Implications for further research are suggested.
KW - aortic stenosis
KW - cardiac imaging and diagnostics
KW - echocardiography
KW - prosthetic heart valves
KW - valvular heart disease
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U2 - 10.1136/heartjnl-2019-315407
DO - 10.1136/heartjnl-2019-315407
M3 - Review article
C2 - 32201373
AN - SCOPUS:85086419807
SN - 1355-6037
VL - 106
SP - 970
EP - 976
JO - Heart
JF - Heart
IS - 13
ER -