Antithrombotic therapy in acute coronary syndromes: Guidelines translated for the clinician

S. Michael Gharacholou, Renato D. Lopes, Jeffrey B. Washam, L. Kristin Newby, Stefan K. James, John H. Alexander

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


The use of anticoagulant and antiplatelet therapy during the management of acute coronary syndromes (ACS) has been associated with improvements in short-and longterm clinical outcomes, regardless of whether patients are managed conservatively or with acute coronary revascularization. Translating the existing evidence for selection of the most appropriate antithrombotic strategy has been summarized in available guideline recommendations. Given the breadth of antithrombotic recommendations across existing U.S. and European guidelines, synthesis of these recommendations for practicing clinicians who treat patients with ACS are increasingly desired. Providing a summary of the similarities across guidelines while noting the areas where divergence exists becomes an important facet in translating optimal antithrombotic management in ACS for the treating clinician. This review highlights the important aspects of clinical practice guidelines that practicing physicians should consider when selecting antithrombotic therapies to reduce ischemic risk while minimizing hemorrhagic risk across all ACS subtypes.

Original languageEnglish (US)
Pages (from-to)516-528
Number of pages13
JournalJournal of Thrombosis and Thrombolysis
Issue number4
StatePublished - May 2010


  • Acute coronary syndromes
  • Antithrombotic therapy
  • Guidelines

ASJC Scopus subject areas

  • Hematology
  • Cardiology and Cardiovascular Medicine


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