Antiphospholipid syndrome and perioperative hemostatic management of cardiac valvular surgery

William J. Hogan, Robert D. McBane, Paula J. Santrach, Elizabeth A. Plumhoff, William C. Oliver, Hartzell V. Schaff, Richard J. Rodeheffer, William D. Edwards, Joseph Duffy, William L. Nichols

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Hemostatic aspects of antiphospholipid syndrome (APS) present unique challenges to clinicians and laboratory personnel alike, particularly in the perioperative period. These challenges are especially evident in patients requiring cardiac valve replacement surgery. However, the literature outlining the optimal approach in such patients is limited. We present the case of a 25-year-old woman with severe aortic regurgitation as a result of APS with particular reference to the precautions necessary during perioperative care. Particularly important are the prevention of thrombotic or hemorrhagic complications, management of associated thrombocytopenia, and laboratory methods of perioperative anticoagulation monitoring in the setting of prolonged clotting times.

Original languageEnglish (US)
Pages (from-to)971-976
Number of pages6
JournalMayo Clinic proceedings
Issue number9
StatePublished - 2000

ASJC Scopus subject areas

  • General Medicine


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