Anticancer efficiency of curcumin-loaded invertible polymer micellar nanoassemblies

Ivan Hevus; Andriy Voronov; Michael J Yaszemski; Avudaiappan Maran; Ananiy Kohut; Stanislav Voronov

doi:10.1016/B978-0-323-46144-3.00014-3

Anticancer efficiency of curcumin-loaded invertible polymer micellar nanoassemblies

Ivan Hevus, Andriy Voronov, Michael J Yaszemski, Avudaiappan Maran, Ananiy Kohut, Stanislav Voronov

Orthopedic Surgery

Research output: Chapter in Book/Report/Conference proceeding › Chapter

4 Scopus citations

Abstract

Recently synthesized amphiphilic invertible polymers (AIPs) are considered as good candidates for micellar delivery of hydrophobic (poorly water-soluble) drugs. Macromolecules of the AIPs self-assemble into invertible micellar assemblies (IMAs) by increasing polymer concentration in solution, and are capable of inverting macromolecular conformation by changing solvent polarity. Being nontoxic against human cells, IMAs are able to solubilize, deliver, and release poorly water-soluble curcumin to treat osteosarcoma cells. The loading into micellar polymer nanoassemblies significantly improves the bioavailability of curcumin in aqueous medium. The mechanism of curcumin release from IMAs depends on AIP chemical structure and might result from macromolecular inversion only, due to changing polarity of the environment. Loaded with curcumin IMAs are stable in aqueous (polar) medium. However, once the drug-loaded assemblies approach cell membrane (less polar), it triggers the macromolecular inversion and drug release due to the enhanced interactions between the membrane and the drug.

Original language	English (US)
Title of host publication	Nanostructures for Cancer Therapy
Publisher	Elsevier Inc.
Pages	351-382
Number of pages	32
ISBN (Electronic)	9780323461504
ISBN (Print)	9780323461443
DOIs	https://doi.org/10.1016/B978-0-323-46144-3.00014-3
State	Published - Apr 14 2017

Keywords

Amphiphilic invertible polymers
Cancer treatment
Curcumin delivery
Invertible micellar nanoassemblies
Smart materials

ASJC Scopus subject areas

Engineering(all)

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10.1016/B978-0-323-46144-3.00014-3

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title = "Anticancer efficiency of curcumin-loaded invertible polymer micellar nanoassemblies",

abstract = "Recently synthesized amphiphilic invertible polymers (AIPs) are considered as good candidates for micellar delivery of hydrophobic (poorly water-soluble) drugs. Macromolecules of the AIPs self-assemble into invertible micellar assemblies (IMAs) by increasing polymer concentration in solution, and are capable of inverting macromolecular conformation by changing solvent polarity. Being nontoxic against human cells, IMAs are able to solubilize, deliver, and release poorly water-soluble curcumin to treat osteosarcoma cells. The loading into micellar polymer nanoassemblies significantly improves the bioavailability of curcumin in aqueous medium. The mechanism of curcumin release from IMAs depends on AIP chemical structure and might result from macromolecular inversion only, due to changing polarity of the environment. Loaded with curcumin IMAs are stable in aqueous (polar) medium. However, once the drug-loaded assemblies approach cell membrane (less polar), it triggers the macromolecular inversion and drug release due to the enhanced interactions between the membrane and the drug.",

keywords = "Amphiphilic invertible polymers, Cancer treatment, Curcumin delivery, Invertible micellar nanoassemblies, Smart materials",

author = "Ivan Hevus and Andriy Voronov and Yaszemski, {Michael J} and Avudaiappan Maran and Ananiy Kohut and Stanislav Voronov",

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AU - Hevus, Ivan

AU - Voronov, Andriy

AU - Yaszemski, Michael J

AU - Maran, Avudaiappan

AU - Kohut, Ananiy

AU - Voronov, Stanislav

PY - 2017/4/14

Y1 - 2017/4/14

N2 - Recently synthesized amphiphilic invertible polymers (AIPs) are considered as good candidates for micellar delivery of hydrophobic (poorly water-soluble) drugs. Macromolecules of the AIPs self-assemble into invertible micellar assemblies (IMAs) by increasing polymer concentration in solution, and are capable of inverting macromolecular conformation by changing solvent polarity. Being nontoxic against human cells, IMAs are able to solubilize, deliver, and release poorly water-soluble curcumin to treat osteosarcoma cells. The loading into micellar polymer nanoassemblies significantly improves the bioavailability of curcumin in aqueous medium. The mechanism of curcumin release from IMAs depends on AIP chemical structure and might result from macromolecular inversion only, due to changing polarity of the environment. Loaded with curcumin IMAs are stable in aqueous (polar) medium. However, once the drug-loaded assemblies approach cell membrane (less polar), it triggers the macromolecular inversion and drug release due to the enhanced interactions between the membrane and the drug.

AB - Recently synthesized amphiphilic invertible polymers (AIPs) are considered as good candidates for micellar delivery of hydrophobic (poorly water-soluble) drugs. Macromolecules of the AIPs self-assemble into invertible micellar assemblies (IMAs) by increasing polymer concentration in solution, and are capable of inverting macromolecular conformation by changing solvent polarity. Being nontoxic against human cells, IMAs are able to solubilize, deliver, and release poorly water-soluble curcumin to treat osteosarcoma cells. The loading into micellar polymer nanoassemblies significantly improves the bioavailability of curcumin in aqueous medium. The mechanism of curcumin release from IMAs depends on AIP chemical structure and might result from macromolecular inversion only, due to changing polarity of the environment. Loaded with curcumin IMAs are stable in aqueous (polar) medium. However, once the drug-loaded assemblies approach cell membrane (less polar), it triggers the macromolecular inversion and drug release due to the enhanced interactions between the membrane and the drug.

KW - Amphiphilic invertible polymers

KW - Cancer treatment

KW - Curcumin delivery

KW - Invertible micellar nanoassemblies

KW - Smart materials

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DO - 10.1016/B978-0-323-46144-3.00014-3

M3 - Chapter

SN - 9780323461443

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EP - 382

BT - Nanostructures for Cancer Therapy

PB - Elsevier Inc.

ER -

Anticancer efficiency of curcumin-loaded invertible polymer micellar nanoassemblies

Abstract

Keywords

ASJC Scopus subject areas

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