Antiarrhythmic drugs and management of ventricular arrhythmias

J. William Schleifer, Komandoor Srivathsan

Research output: Chapter in Book/Report/Conference proceedingChapter


While many advances have occurred in the nonpharmacologic treatment of ventricular arrhythmias, antiarrhythmic medications remain indispensable in the acute treatment and prevention of recurrent ventricular arrhythmias. Additionally, it is important to understand the effects of medications on neurohormonal modulation and defibrillation thresholds. Some antiarrhythmics have specialized uses for specific arrhythmias, and some can be used in the electrophysiology lab for diagnostic testing and aid during ablations. In contrast, amiodarone is effective for various arrhythmias, but it has many extracardiac toxicities. This chapter discusses the pharmacology and clinical use of antiarrhythmics for diagnostic and therapeutic management of ventricular arrhythmias.

Original languageEnglish (US)
Title of host publicationPathophysiology and Pharmacotherapy of Cardiovascular Disease
PublisherSpringer International Publishing
Number of pages33
ISBN (Electronic)9783319159614
ISBN (Print)9783319159607
StatePublished - Jan 1 2015


  • Amiodarone
  • Antiarrhythmic medications
  • Cardioversion
  • ICD
  • Potassium channel blocker
  • QT interval
  • Sodium channel blocker
  • Ventricular arrhythmia
  • Ventricular fibrillation
  • Ventricular tachycardia

ASJC Scopus subject areas

  • General Pharmacology, Toxicology and Pharmaceutics
  • General Medicine


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