Antiangiogenic properties of gold nanoparticles

Priyabrata Mukherjee, Resham Bhattacharya, Ping Wang, Ling Wang, Sujit Basu, Janice A. Nagy, Anthony Atala, Debabrata Mukhopadhyay, Shay Soker

Research output: Contribution to journalArticlepeer-review

355 Scopus citations


Here, we report an intrinsic property of gold nanoparticles (nanogold): they can interact selectively with heparin-binding glycoproteins and inhibit their activity. Gold nanoparticles specifically bound vascular permeability factor/vascular endothelial growth factor (VPF/VEGF)-165 and basic fibroblast growth factor, two endothetial cell mitogens and mediators of angiogenesis resulting in inhibition of endothelial/fibroblast cell proliferation in vitro and VEGF-induced permeability as well as angiogenesis in vivo. In contrast, nanogold did not inhibit VEGF-121 or epidermal growth factor, two non-heparin-binding growth factors, mediated cell proliferation. Gold nanoparticles significantly inhibited VEGF receptor-2 phosphorylation, intracellular calcium release, and migration and RhoA activation in vitro. These results report for the first time a novel property of gold nanoparticles to bind heparin-binding proteins and thereby inhibit their subsequent signaling events.

Original languageEnglish (US)
Pages (from-to)3530-3534
Number of pages5
JournalClinical Cancer Research
Issue number9
StatePublished - May 1 2005

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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