Anti-Neutrophil Cytoplasmic Autoantibodies

Ulrich Specks, Michael S. Rohrbach, Richard A. Deremee, J. Charles Jennette, Ronald J. Falk

Research output: Contribution to journalLetterpeer-review

28 Scopus citations


To the Editor: We commend Drs. Falk and Jennette (June 23 issue)1 for their important observation that at least two types of antibodies against neutrophil components may be present in the serum of patients with various forms of systemic vasculitis. However, on the basis of previous reports2 3 4 5 6 7 8 and our own experience9 with autoantibodies against cytoplasmic components of neutrophils and monocytes (ACPA), also called anti-neutrophil cytoplasmic antibodies by some investigators,5,10 we do not agree with the conclusions drawn by Falk and Jennette. The antibodies described in previous publications2 3 4 5 6 7 8 cause a characteristic staining pattern of fine granular, centrally accentuated immunofluorescence in the.

Original languageEnglish (US)
Pages (from-to)1416-1417
Number of pages2
JournalNew England Journal of Medicine
Issue number21
StatePublished - Nov 24 1988

ASJC Scopus subject areas

  • Medicine(all)


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