Abstract
Using radioligand binding techniques and human frontal cortex, we determined the equilibrium dissociation constants (KDS) of 17 neuroleptics at the serotonin 5-HT1A and serotonin 5-HT2 receptors with [3H]WB4101 and [3H]ketanserin, respectively. At the serotonin 5-HT1A receptor, the most and least potent neuroleptics were chlorprothixene (KD = 230 nM) and fluphenazine (KD = 40 μM), respectively. At the serotonin 5-HT2 receptor, the most and least potent neuroleptics were spiperone (KD = 0.38 nM)and molindone, (KD = 5 μM), respectively.
Original language | English (US) |
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Pages (from-to) | 279-282 |
Number of pages | 4 |
Journal | European Journal of Pharmacology |
Volume | 143 |
Issue number | 2 |
DOIs | |
State | Published - Nov 10 1987 |
Keywords
- (Human)
- Brain
- Neuroleptics
- Serotonin receptors
ASJC Scopus subject areas
- Pharmacology