Annual Outcomes with Transcatheter Valve Therapy from the STS/ACC TVT Registry

David R. Holmes, Rick A. Nishimura, Frederick L. Grover, Ralph G. Brindis, John D. Carroll, Fred H. Edwards, Eric D. Peterson, John S. Rumsfeld, David M. Shahian, Vinod H. Thourani, E. Murat Tuzcu, Sreekanth Vemulapalli, Kathleen Hewitt, Joan Michaels, Susan Fitzgerald, Michael J. Mack

Research output: Contribution to journalArticlepeer-review

168 Scopus citations


Background The Society of Thoracic Surgeons (STS)/American College of Cardiology (ACC) Transcatheter Valve Therapy (TVT) Registry has been a joint initiative of the STS and the ACC in concert with multiple stakeholders. The TVT Registry has important information regarding patient selection, delivery of care, science, education, and research in the field of structural valvular heart disease. Objectives This report provides an overview on current U.S. TVT practice and trends. The emphasis is on demographics, in-hospital procedural characteristics, and outcomes of patients having transcatheter aortic valve replacement (TAVR) performed at 348 U.S. centers. Methods The TVT Registry captured 26,414 TAVR procedures as of December 31, 2014. Temporal trends between 2012 and 2013 versus 2014 were compared. Results Comparison of the 2 time periods reveals that TAVR patients remain elderly (mean age 82 years), with multiple comorbidities, reflected by a high mean STS predicted risk of mortality (STS PROM) for surgical valve replacement (8.34%), were highly symptomatic (New York Heart Association functional class III/IV in 82.5%), frail (slow 5-m walk test in 81.6%), and have poor self-reported health status (median baseline Kansas City Cardiomyopathy Questionnaire score of 39.1). Procedure performance is changing, with an increased use of moderate sedation (from 1.6% to 5.1%) and increase in femoral access using percutaneous techniques (66.8% in 2014). Vascular complication rates are decreasing (from 5.6% to 4.2%), whereas site-reported stroke rates remain stable at 2.2%. Conclusions The TVT Registry provides important information on characteristics and outcomes of TAVR in contemporary U.S. clinical practice. It can be used to identify trends in practice and opportunities for quality improvement.

Original languageEnglish (US)
Pages (from-to)2813-2823
Number of pages11
JournalJournal of the American College of Cardiology
Issue number25
StatePublished - Dec 29 2015


  • VARC
  • aortic stenosis
  • aortic valve replacement
  • transcatheter aortic valve replacement
  • valvular heart disease

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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