Animal models for studying the etiology and treatment of low back pain

Changgui Shi, Sujun Qiu, Scott M. Riester, Vaskar Das, Bingqian Zhu, Atiyayein A. Wallace, Andre J. van Wijnen, Fackson Mwale, James C. Iatridis, Daisuke Sakai, Gina Votta-Velis, Wen Yuan, Hee Jeong Im

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations


Chronic low back pain is a major cause of disability and health care costs. Effective treatments are inadequate for many patients. Animal models are essential to further understanding of the pain mechanism and testing potential therapies. Currently, a number of preclinical models have been developed attempting to mimic aspects of clinical conditions that contribute to low back pain (LBP). This review focused on describing these animal models and the main behavioral tests for assessing pain in each model. Animal models of LBP can be divided into the following five categories: Discogenic LBP, radicular back pain, facet joint osteoarthritis back pain, muscle-induced LBP, and spontaneous occurring LBP models. These models are important not only for enhancing our knowledge of how LBP is generated, but also for the development of novel therapeutic regimens to treat LBP in patients.

Original languageEnglish (US)
Pages (from-to)1305-1312
Number of pages8
JournalJournal of Orthopaedic Research
Issue number5
StatePublished - May 2018


  • animal model
  • discogenic pain
  • dorsal root ganglia
  • low back pain
  • pain assessment
  • spinal cord

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine


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