@article{7f580977b161467687a126200d53143f,
title = "Animal models for studying the etiology and treatment of low back pain",
abstract = "Chronic low back pain is a major cause of disability and health care costs. Effective treatments are inadequate for many patients. Animal models are essential to further understanding of the pain mechanism and testing potential therapies. Currently, a number of preclinical models have been developed attempting to mimic aspects of clinical conditions that contribute to low back pain (LBP). This review focused on describing these animal models and the main behavioral tests for assessing pain in each model. Animal models of LBP can be divided into the following five categories: Discogenic LBP, radicular back pain, facet joint osteoarthritis back pain, muscle-induced LBP, and spontaneous occurring LBP models. These models are important not only for enhancing our knowledge of how LBP is generated, but also for the development of novel therapeutic regimens to treat LBP in patients.",
keywords = "animal model, discogenic pain, dorsal root ganglia, low back pain, pain assessment, spinal cord",
author = "Changgui Shi and Sujun Qiu and Riester, {Scott M.} and Vaskar Das and Bingqian Zhu and Wallace, {Atiyayein A.} and {van Wijnen}, {Andre J.} and Fackson Mwale and Iatridis, {James C.} and Daisuke Sakai and Gina Votta-Velis and Wen Yuan and Im, {Hee Jeong}",
note = "Funding Information: Changgui Shi and Sujun Qiu contributed equally to this work. Conflicts of interest: None. Grant sponsor: VA BLD&R Merit Review Award; Grant number: I01BC002647; Grant sponsor: Foundation for the National Institutes of Health; Grant numbers: AR062136, AR067935; Grant sponsor: Arthritis Foundation. Correspondence to: Hee-Jeong Im and Wen Yuan (T: 312.569.7871 [H.-J. I.], +86-21-81885637 [W. Y.]; F: 312.569.8114 [H.-J. I.], +86-21-63520020 [W. Y.]; E-mail: hee-jeong.sampen@va.gov [H.-J. I.], smmuyuanwen@163.com [W. Y.]) Funding Information: This work was supported by a VA BLD&R Merit Review Award (I01BC002647) to HJI; an NIH NIAMS R01 (AR062136) and R21 grant (AR067935) to HJI; and Arthritis Foundation to HJI. Publisher Copyright: {\textcopyright} 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.",
year = "2018",
month = may,
doi = "10.1002/jor.23741",
language = "English (US)",
volume = "36",
pages = "1305--1312",
journal = "Journal of Orthopaedic Research",
issn = "0736-0266",
publisher = "John Wiley and Sons Inc.",
number = "5",
}