Aneuploidy in health, disease, and aging

Robin M. Ricke, Jan M. Van Deursen

Research output: Contribution to journalReview articlepeer-review

78 Scopus citations


Aneuploidy, an aberrant number of chromosomes, has been recognized as a feature of human malignancies for over a century, but compelling evidence for causality was largely lacking until mouse models for chromosome number instability were used. These in vivo studies have not only uncovered important new insights into the extremely complex aneuploidy-cancer relationship but also into the molecular mechanisms underlying proper and aberrant chromosome segregation. A series of diverse mouse models for the mitotic checkpoint protein BubR1 has provided evidence for a provocative novel link between aneuploidization and the development of age-related pathologies.

Original languageEnglish (US)
Pages (from-to)11-21
Number of pages11
JournalJournal of Cell Biology
Issue number1
StatePublished - Apr 2013

ASJC Scopus subject areas

  • Cell Biology


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