Anesthetic-Related Neurotoxicity and Neuroimaging in Children: A Call for Conversation

Kara A. Bjur, Eric T. Payne, Michael E. Nemergut, Danqing Hu, Randall P. Flick

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations


Each year millions of young children undergo procedures requiring sedation or general anesthesia. An increasing proportion of the anesthetics used are provided to optimize diagnostic imaging studies such as magnetic resonance imaging. Concern regarding the neurotoxicity of sedatives and anesthetics has prompted the US Food and Drug Administration to change labeling of anesthetics and sedative agents warning against repeated or prolonged exposure in young children. This review aims to summarize the risk of anesthesia in children with an emphasis on anesthetic-related neurotoxicity, acknowledge the value of pediatric neuroimaging, and address this call for conversation.

Original languageEnglish (US)
Pages (from-to)594-602
Number of pages9
JournalJournal of child neurology
Issue number6
StatePublished - May 1 2017


  • anesthesia
  • anesthetic
  • children
  • diagnostic imaging
  • magnetic resonance imaging
  • neurodevelopment
  • neuroimaging
  • neurotoxicity
  • sedation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology


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