Anesthetic considerations for patients on psychotropic drug therapies

Monica W. Harbell, Catalina Dumitrascu, Layne Bettini, Soojie Yu, Cameron M. Thiele, Veerandra Koyyalamudi

Research output: Contribution to journalReview articlepeer-review


Psychotropic drugs are used in the treatment of psychiatric and non-psychiatric conditions. Many patients who are on psychotropic medications may present for procedures requiring anesthesia. Psychotropic medications can have dangerous interactions with drugs commonly used in anesthesia, some of which can be life-threatening. In this review, we describe the current anesthetic considerations for patients on psychotropic drug therapies, including antidepressants, antipsychotics, mood stabilizers, anxiolytics, and stimulants. The pharmacology, side effects, and potential drug interactions of the commonly prescribed psychotropic drug therapies with anesthetic agents are described. Further, we highlight the current recommendations regarding the cessation and continuation of these medications during the perioperative period.

Original languageEnglish (US)
Pages (from-to)640-658
Number of pages19
JournalNeurology International
Issue number4
StatePublished - Dec 2021


  • Anesthesia
  • Anesthetics
  • Antidepressive agents
  • Antipsychotic agents
  • Drug interactions
  • Perioperative period
  • Psychotropic drugs

ASJC Scopus subject areas

  • Clinical Neurology


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