@article{d3567fc6c84444d3a4ac76c4921f124b,
title = "Anemia during SARS-CoV-2 infection is associated with rehospitalization after viral clearance",
abstract = "Patients with COVID-19 can experience symptoms and complications after viral clearance. It is important to identify clinical features of patients who are likely to experience these prolonged effects. We conducted a retrospective study to compare longitudinal laboratory test measurements (hemoglobin, hematocrit, estimated glomerular filtration rate, serum creatinine, and blood urea nitrogen) in patients rehospitalized after PCR-confirmed SARS-CoV-2 clearance (n = 104) versus patients not rehospitalized after viral clearance (n = 278). Rehospitalized patients had lower median hemoglobin levels in the year prior to COVID-19 diagnosis (Cohen's D = −0.50; p = 1.2 × 10−3) and during their active SARS-CoV-2 infection (Cohen's D = −0.71; p = 4.6 × 10−8). Rehospitalized patients were also more likely to be diagnosed with moderate or severe anemia during their active infection (Odds Ratio = 4.07; p = 4.99 × 10−9). These findings suggest that anemia-related laboratory tests should be considered in risk stratification algorithms for patients with COVID-19.",
keywords = "Pathophysiology, Virology",
author = "Lenehan, {Patrick J.} and Eshwan Ramudu and Venkatakrishnan, {A. J.} and Gabriela Berner and Reid McMurry and O'Horo, {John C.} and Badley, {Andrew D.} and William Morice and John Halamka and Venky Soundararajan",
note = "Funding Information: We thank Murali Aravamudan for his thoughtful review and feedback on this manuscript. We also thank Andrew Danielsen, Jason Ross, Jeff Anderson, and Sankar Ardhanari for their support that enabled the rapid completion of this study. This study was funded by nference. P.J.L. E.R. A.J.V. R.M. A.D.B. and V.S. contributed to the study design and methodology. E.R. G.B. and J.C.O. were responsible for data curation. E.R. performed the formal statistical analyses, which were reviewed by P.J.L. A.J.V. R.M. and V.S. P.J.L. drafted the manuscript with inputs from E.R. A.J.V. R.M. J.C.O. A.D.B. W.M. J.H. and V.S. provided critical revisions, which were incorporated into the final manuscript by P.J.L. All authors approved the submitted version of the manuscript. P.J.L. E.R. A.J.V. G.B. R.M. and V.S. are employees of nference and have financial interests in the company. J.C.O. receives personal fees from Elsevier and Bates College, and receives small grants from nference, Inc, outside the submitted work. A.D.B. is a consultant for Abbvie, is on scientific advisory boards for nference and Zentalis, and is founder and President of Splissen therapeutics. J.C.O. W.M. J.H. and A.D.B. are employees of the Mayo Clinic. The Mayo Clinic may stand to gain financially from the successful outcome of the research. Publisher Copyright: {\textcopyright} 2021",
year = "2021",
month = jul,
day = "23",
doi = "10.1016/j.isci.2021.102780",
language = "English (US)",
volume = "24",
journal = "iScience",
issn = "2589-0042",
publisher = "Elsevier Inc.",
number = "7",
}