Androgen Action in Prostate Cancer

Sujit Basu; Donald J. Tindall

doi:10.1007/s12672-010-0044-4

Androgen Action in Prostate Cancer

Sujit Basu, Donald J. Tindall

Urology

Research output: Contribution to journal › Review article › peer-review

25 Scopus citations

Abstract

Prostate cancer represents a major health problem in men worldwide. Androgens are required for the growth and maintenance of the prostate. Androgens act by binding to the androgen receptor (AR), a nuclear receptor transcription factor present in the prostate tissues. Most prostate tumors also retain their androgen dependence; therefore, androgen ablation is usually the preferred initial therapeutic approach for the treatment of advanced prostate cancer patients. This review summarizes the current information regarding the role of androgens in prostate cancer.

Original language	English (US)
Pages (from-to)	223-228
Number of pages	6
Journal	Hormones and Cancer
Volume	1
Issue number	5
DOIs	https://doi.org/10.1007/s12672-010-0044-4
State	Published - Oct 2010

Keywords

Androgen
Androgen ablation therapy
Prostate

ASJC Scopus subject areas

General Medicine

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10.1007/s12672-010-0044-4

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abstract = "Prostate cancer represents a major health problem in men worldwide. Androgens are required for the growth and maintenance of the prostate. Androgens act by binding to the androgen receptor (AR), a nuclear receptor transcription factor present in the prostate tissues. Most prostate tumors also retain their androgen dependence; therefore, androgen ablation is usually the preferred initial therapeutic approach for the treatment of advanced prostate cancer patients. This review summarizes the current information regarding the role of androgens in prostate cancer.",

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AB - Prostate cancer represents a major health problem in men worldwide. Androgens are required for the growth and maintenance of the prostate. Androgens act by binding to the androgen receptor (AR), a nuclear receptor transcription factor present in the prostate tissues. Most prostate tumors also retain their androgen dependence; therefore, androgen ablation is usually the preferred initial therapeutic approach for the treatment of advanced prostate cancer patients. This review summarizes the current information regarding the role of androgens in prostate cancer.

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KW - Androgen ablation therapy

KW - Prostate

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Androgen Action in Prostate Cancer

Abstract

Keywords

ASJC Scopus subject areas

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