Anaphylaxis

Lorenzo Hernandez; Sarah Papalia; George G.A. Pujalte

doi:10.1016/j.pop.2016.04.002

Anaphylaxis

Lorenzo Hernandez, Sarah Papalia, George G.A. Pujalte

Family Medicine

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

Anaphylaxis is an acute, systemic reaction mediated by immunoglobulin E hypersensitivity. Release of bioactive factors causes vasodilation and bronchiole constriction that can lead to hypotensive shock and asphyxiation. Differential diagnosis includes acute asthma, localized angioedema, syncope, and anxiety/panic attacks. Diagnostic tests lack specificity. Clinical diagnosis is based on demonstration of specific airway or cardiovascular compromise within proximity of allergen exposure. Treatment includes epinephrine, antihistamines, fluid resuscitation, and airway management. Prevention focuses on awareness/avoidance of triggers, implementation of personalized action plans, as well as immune modulation by desensitization in a closely controlled setting where available.

Original language	English (US)
Pages (from-to)	477-485
Number of pages	9
Journal	Primary Care - Clinics in Office Practice
Volume	43
Issue number	3
DOIs	https://doi.org/10.1016/j.pop.2016.04.002
State	Published - Sep 1 2016

Keywords

Allergen
Anaphylaxis
Angioedema
Bronchospasm
Epinephrine
Hypersensitivity
IgE
Shock

ASJC Scopus subject areas

Pharmacology (medical)

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10.1016/j.pop.2016.04.002

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title = "Anaphylaxis",

abstract = "Anaphylaxis is an acute, systemic reaction mediated by immunoglobulin E hypersensitivity. Release of bioactive factors causes vasodilation and bronchiole constriction that can lead to hypotensive shock and asphyxiation. Differential diagnosis includes acute asthma, localized angioedema, syncope, and anxiety/panic attacks. Diagnostic tests lack specificity. Clinical diagnosis is based on demonstration of specific airway or cardiovascular compromise within proximity of allergen exposure. Treatment includes epinephrine, antihistamines, fluid resuscitation, and airway management. Prevention focuses on awareness/avoidance of triggers, implementation of personalized action plans, as well as immune modulation by desensitization in a closely controlled setting where available.",

keywords = "Allergen, Anaphylaxis, Angioedema, Bronchospasm, Epinephrine, Hypersensitivity, IgE, Shock",

author = "Lorenzo Hernandez and Sarah Papalia and Pujalte, {George G.A.}",

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AU - Hernandez, Lorenzo

AU - Papalia, Sarah

AU - Pujalte, George G.A.

PY - 2016/9/1

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N2 - Anaphylaxis is an acute, systemic reaction mediated by immunoglobulin E hypersensitivity. Release of bioactive factors causes vasodilation and bronchiole constriction that can lead to hypotensive shock and asphyxiation. Differential diagnosis includes acute asthma, localized angioedema, syncope, and anxiety/panic attacks. Diagnostic tests lack specificity. Clinical diagnosis is based on demonstration of specific airway or cardiovascular compromise within proximity of allergen exposure. Treatment includes epinephrine, antihistamines, fluid resuscitation, and airway management. Prevention focuses on awareness/avoidance of triggers, implementation of personalized action plans, as well as immune modulation by desensitization in a closely controlled setting where available.

AB - Anaphylaxis is an acute, systemic reaction mediated by immunoglobulin E hypersensitivity. Release of bioactive factors causes vasodilation and bronchiole constriction that can lead to hypotensive shock and asphyxiation. Differential diagnosis includes acute asthma, localized angioedema, syncope, and anxiety/panic attacks. Diagnostic tests lack specificity. Clinical diagnosis is based on demonstration of specific airway or cardiovascular compromise within proximity of allergen exposure. Treatment includes epinephrine, antihistamines, fluid resuscitation, and airway management. Prevention focuses on awareness/avoidance of triggers, implementation of personalized action plans, as well as immune modulation by desensitization in a closely controlled setting where available.

KW - Allergen

KW - Anaphylaxis

KW - Angioedema

KW - Bronchospasm

KW - Epinephrine

KW - Hypersensitivity

KW - IgE

KW - Shock

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Anaphylaxis

Abstract

Keywords

ASJC Scopus subject areas

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