AnalyzeNNLS: Magnetic resonance multiexponential decay image analysis

Thorarin A. Bjarnason, J. Ross Mitchell

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Exponential decays are fundamental to magnetic resonance imaging, yet adequately sampling and analyzing multiexponential decays is rarely attempted. The advantage of multiexponential analysis is the quantification of sub-voxel structure caused by water compartmentalization, with application as a non-invasive imaging biomarker for myelin. We have developed AnalyzeNNLS, software designed specifically for multiexponential decay image analysis that has a user-friendly graphical user interface and can analyze data from many MR manufacturers. AnalyzeNNLS is a simple, platform independent analysis tool that was created using the extensive mathematical and visualization libraries in Matlab, and released as open source code allowing scientists to evaluate, scrutinize, improve, and expand.

Original languageEnglish (US)
Pages (from-to)200-204
Number of pages5
JournalJournal of Magnetic Resonance
Issue number2
StatePublished - Oct 2010


  • Magnetic resonance
  • Matlab
  • Multiexponential analysis
  • Quantitative T
  • Visualization

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Nuclear and High Energy Physics
  • Condensed Matter Physics


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