Analytic Result Variation for High-Sensitivity Cardiac Troponin: Interpretation and Consequences

Peter A. Kavsak; Lorna Clark; Saranya Arnoldo; Amy Lou; Jennifer L. Shea; Shaun Eintracht; Andrew W. Lyon; Vipin Bhayana; Laurel Thorlacius; Joshua E. Raizman; Albert K.Y. Tsui; Rose Djiana; Michael Chen; Yun Huang; Ronald A. Booth; Chris McCudden; Joël Lavoie; Daniel R. Beriault; David W. Blank; Angela W.S. Fung; Barry Hoffman; Jennifer Taher; Julie St-Cyr; Paul M. Yip; Emilie P. Belley-Cote; Beth L. Abramson; Bjug Borgundvaag; Steven M. Friedman; Susanna Mak; Jesse McLaren; Brian Steinhart; Jacob A. Udell; Harindra C. Wijeysundera; Paul Atkinson; Samuel G. Campbell; Kavish Chandra; Jafna L. Cox; Sharon Mulvagh; Ata ur Rehman Quraishi; Annabel Chen-Tournoux; Gregory Clark; Eli Segal; Neville Suskin; Amer M. Johri; Marco L.A. Sivilotti; Habibat Garuba; Venkatesh Thiruganasambandamoorthy; Simon Robinson; Frank Scheuermeyer; Karin H. Humphries; Martin Than; John W. Pickering; Andrew Worster; Nicholas L. Mills; P. J. Devereaux; Allan S. Jaffe

doi:10.1016/j.cjca.2023.04.013

Analytic Result Variation for High-Sensitivity Cardiac Troponin: Interpretation and Consequences

Peter A. Kavsak, Lorna Clark, Saranya Arnoldo, Amy Lou, Jennifer L. Shea, Shaun Eintracht, Andrew W. Lyon, Vipin Bhayana, Laurel Thorlacius, Joshua E. Raizman, Albert K.Y. Tsui, Rose Djiana, Michael Chen, Yun Huang, Ronald A. Booth, Chris McCudden, Joël Lavoie, Daniel R. Beriault, David W. Blank, Angela W.S. FungBarry Hoffman, Jennifer Taher, Julie St-Cyr, Paul M. Yip, Emilie P. Belley-Cote, Beth L. Abramson, Bjug Borgundvaag, Steven M. Friedman, Susanna Mak, Jesse McLaren, Brian Steinhart, Jacob A. Udell, Harindra C. Wijeysundera, Paul Atkinson, Samuel G. Campbell, Kavish Chandra, Jafna L. Cox, Sharon Mulvagh, Ata ur Rehman Quraishi, Annabel Chen-Tournoux, Gregory Clark, Eli Segal, Neville Suskin, Amer M. Johri, Marco L.A. Sivilotti, Habibat Garuba, Venkatesh Thiruganasambandamoorthy, Simon Robinson, Frank Scheuermeyer, Karin H. Humphries, Martin Than, John W. Pickering, Andrew Worster, Nicholas L. Mills, P. J. Devereaux, Allan S. Jaffe

Cardiovascular Medicine

Research output: Contribution to journal › Article › peer-review

Original language	English (US)
Pages (from-to)	947-951
Number of pages	5
Journal	Canadian Journal of Cardiology
Volume	39
Issue number	7
DOIs	https://doi.org/10.1016/j.cjca.2023.04.013
State	Published - Jul 2023

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.cjca.2023.04.013

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Kavsak, P. A., Clark, L., Arnoldo, S., Lou, A., Shea, J. L., Eintracht, S., Lyon, A. W., Bhayana, V., Thorlacius, L., Raizman, J. E., Tsui, A. K. Y., Djiana, R., Chen, M., Huang, Y., Booth, R. A., McCudden, C., Lavoie, J., Beriault, D. R., Blank, D. W., ... Jaffe, A. S. (2023). Analytic Result Variation for High-Sensitivity Cardiac Troponin: Interpretation and Consequences. Canadian Journal of Cardiology, 39(7), 947-951. https://doi.org/10.1016/j.cjca.2023.04.013

Kavsak, PA, Clark, L, Arnoldo, S, Lou, A, Shea, JL, Eintracht, S, Lyon, AW, Bhayana, V, Thorlacius, L, Raizman, JE, Tsui, AKY, Djiana, R, Chen, M, Huang, Y, Booth, RA, McCudden, C, Lavoie, J, Beriault, DR, Blank, DW, Fung, AWS, Hoffman, B, Taher, J, St-Cyr, J, Yip, PM, Belley-Cote, EP, Abramson, BL, Borgundvaag, B, Friedman, SM, Mak, S, McLaren, J, Steinhart, B, Udell, JA, Wijeysundera, HC, Atkinson, P, Campbell, SG, Chandra, K, Cox, JL, Mulvagh, S, Quraishi, AUR, Chen-Tournoux, A, Clark, G, Segal, E, Suskin, N, Johri, AM, Sivilotti, MLA, Garuba, H, Thiruganasambandamoorthy, V, Robinson, S, Scheuermeyer, F, Humphries, KH, Than, M, Pickering, JW, Worster, A, Mills, NL, Devereaux, PJ & Jaffe, AS 2023, 'Analytic Result Variation for High-Sensitivity Cardiac Troponin: Interpretation and Consequences', Canadian Journal of Cardiology, vol. 39, no. 7, pp. 947-951. https://doi.org/10.1016/j.cjca.2023.04.013

@article{3bd6abad93b74be896351a4fed49f27f,

title = "Analytic Result Variation for High-Sensitivity Cardiac Troponin: Interpretation and Consequences",

author = "Kavsak, {Peter A.} and Lorna Clark and Saranya Arnoldo and Amy Lou and Shea, {Jennifer L.} and Shaun Eintracht and Lyon, {Andrew W.} and Vipin Bhayana and Laurel Thorlacius and Raizman, {Joshua E.} and Tsui, {Albert K.Y.} and Rose Djiana and Michael Chen and Yun Huang and Booth, {Ronald A.} and Chris McCudden and Jo{\"e}l Lavoie and Beriault, {Daniel R.} and Blank, {David W.} and Fung, {Angela W.S.} and Barry Hoffman and Jennifer Taher and Julie St-Cyr and Yip, {Paul M.} and Belley-Cote, {Emilie P.} and Abramson, {Beth L.} and Bjug Borgundvaag and Friedman, {Steven M.} and Susanna Mak and Jesse McLaren and Brian Steinhart and Udell, {Jacob A.} and Wijeysundera, {Harindra C.} and Paul Atkinson and Campbell, {Samuel G.} and Kavish Chandra and Cox, {Jafna L.} and Sharon Mulvagh and Quraishi, {Ata ur Rehman} and Annabel Chen-Tournoux and Gregory Clark and Eli Segal and Neville Suskin and Johri, {Amer M.} and Sivilotti, {Marco L.A.} and Habibat Garuba and Venkatesh Thiruganasambandamoorthy and Simon Robinson and Frank Scheuermeyer and Humphries, {Karin H.} and Martin Than and Pickering, {John W.} and Andrew Worster and Mills, {Nicholas L.} and Devereaux, {P. J.} and Jaffe, {Allan S.}",

note = "Funding Information: Special thanks for the following individuals who helped in this prospective study: Chantele Roy, Paul Malinowski, and Tara Bryce (CRLB-GMEL, Hamilton Health Sciences, Hamilton, ON); Nadia Caruso (Juravinski Hospital and Cancer Centre, Hamilton ON); Vathany Kulasingam (University Health Network, Toronto, ON); Mark Cheung (Sunnybrook Hospital, Toronto, ON); Viktor Skihar, Joshua Buse, Jan Feser, and Christina Bacalso (Regina General Hospital, Regina, SK); Janet Simons and Laura Burns (St Paul's Hospital, Vancouver, BC); Allyse Hummelman (Mount Saint Joseph Hospital, Vancouver, BC); Jennifer Annand, Robyn Dahl, and Sabrina Hocken (Victoria General Hospital, Victoria, BC); Marisa Schneider, Maryann Jiang, and Darryl Holden (Royal Jubilee Hospital, Victoria, BC); Krista McComb, Eric (Phong) Ly, Carmen Zimmer, and Christina Gauvreau (University of Alberta Hospital, Edmonton, AB); Rob Saunders (St Paul's Hospital, Saskatoon, SK); Connie, Neuberger and Karen Nogier (Royal University Hospital, Saskatoon, SK); Kari Henwood, Jeffrey Noel, and JoAnne Novakowski (St. Boniface Hospital, Winnipeg, MB); Debbie Kiel and Meghan Rasmussen (Selkirk Regional Health Centre, Selkirk, MB); Katie Ndukwu and Steven Cong (Health Sciences Centre,Winnipeg, MB); Roy Augustin and Fari Rokhforooz (Mount Sinai Hospital, Toronto, ON); Bonny Lem Ragosnig and Liyan Ma (Sunnybrook Hospital, Toronto, ON); Sarah Lam (Toronto General Hospital, Toronto, ON); Julia (Qiu Yi) Shao (St Michael's Hospital, Toronto, ON); Robert Dean and Leanne Reilly (Kingston General Hospital, Kingston, ON); Emma Greenough, Isla Craig, and Alan Burgess (Ottawa Hospital—Civic Campus, Ottawa, ON); Sarah Cascanette, Janette Rutledge, Guylaine Imbeault, and Sandy Bookalam (Ottawa Hospital—General Campus, Ottawa, ON); Purvi Patel (Brampton Civic Hospital, Brampton ON); Linda Stevenson (Etobicoke General Hospital, Etobicoke, ON); Lisa Brown (Peel Memorial Centre for Integrated Health and Wellness, Brampton, ON); Husam Abdoh (LHSC—Victoria Hospital, London, ON); Bill Richardson, Kylie, McInerney, and Rick Moore (LHSC—University Hospital, London, ON); Nathalie Payette, Gloria Marcaida, Kruno Lorkovic, and Maryse Coderre (Hopital General de Montr{\'e}al, Montr{\'e}al, QC); Lisa Murphy, Maia Stallone, and Ana Marcaida (Le Site Glen, Montr{\'e}al, QC), Micheline Masangya (St Mary's Hospital Center, Montr{\'e}al, QC); Youcef Amimer (Institut de Cardiologie, de Montr{\'e}al, Montr{\'e}al, QC); Rianne Madriaga, Oktavian Toka, Safiya Sweeney, and Girupan Arasaratman (Jewish General Hospital, Montr{\'e}al, QC), Ashley Stevens, Tiffany Moore, and Christina Quondam Franks (Saint John Regional Hospital, Saint John, NB); Ian MacLean, Sandy Schlay, and Rebecca Reid (Queen Elizabeth II Health Sciences Centre, Halifax, NS); Kathleen Lawrence and Kelly Smith (Dartmouth General Hospital, Dartmouth, NS); Rose Bartlett, Craig Leblanc, Shelley Strong, and Shannah Hynes (Cobequid Community Health Centre, Lower Sackville, NS); Kimberly Ross and Jenilee Calbury (Hants Community Hospital, Windsor, NS); Trish Jarvie, Jill Boreyko, Ronda Snowdy, Binal Parikhb, and Trisha Bellamy (Hamilton General Hospital, Hamilton, ON); Ching Mark, Elspeth Millar, Brian Vandermey, and Leesa Lillie (Juravinski Hospital and Cancer Centre, Hamilton, ON); Matthew Hulett and Glen Edmunds (West Lincoln Memorial Hospital, Grimsby, ON); and the CODE-MI study. Funding was provided by a grant from the Canadian Institutes of Health Research (to Dr Kavsak) and a Chair Award, Programme Grant, and Research Excellence Award (CH/F/21/90010, RG/20/10/34966, RE/18/5/34216) from the British Heart Foundation (to Dr Mills). The funding organisations had no role in the design and conduct of the study; in the collection, analysis, and interpretation of the data; or in the final approval of the manuscript. See Supplemental Appendix S1 for disclosures. Funding Information: Funding was provided by a grant from the Canadian Institutes of Health Research (to Dr Kavsak) and a Chair Award, Programme Grant, and Research Excellence Award (CH/F/21/90010, RG/20/10/34966, RE/18/5/34216) from the British Heart Foundation (to Dr Mills). The funding organisations had no role in the design and conduct of the study; in the collection, analysis, and interpretation of the data; or in the final approval of the manuscript. ",

year = "2023",

month = jul,

doi = "10.1016/j.cjca.2023.04.013",

language = "English (US)",

volume = "39",

pages = "947--951",

journal = "Canadian Journal of Cardiology",

issn = "0828-282X",

publisher = "Pulsus Group Inc.",

number = "7",

}

TY - JOUR

T1 - Analytic Result Variation for High-Sensitivity Cardiac Troponin

T2 - Interpretation and Consequences

AU - Kavsak, Peter A.

AU - Clark, Lorna

AU - Arnoldo, Saranya

AU - Lou, Amy

AU - Shea, Jennifer L.

AU - Eintracht, Shaun

AU - Lyon, Andrew W.

AU - Bhayana, Vipin

AU - Thorlacius, Laurel

AU - Raizman, Joshua E.

AU - Tsui, Albert K.Y.

AU - Djiana, Rose

AU - Chen, Michael

AU - Huang, Yun

AU - Booth, Ronald A.

AU - McCudden, Chris

AU - Lavoie, Joël

AU - Beriault, Daniel R.

AU - Blank, David W.

AU - Fung, Angela W.S.

AU - Hoffman, Barry

AU - Taher, Jennifer

AU - St-Cyr, Julie

AU - Yip, Paul M.

AU - Belley-Cote, Emilie P.

AU - Abramson, Beth L.

AU - Borgundvaag, Bjug

AU - Friedman, Steven M.

AU - Mak, Susanna

AU - McLaren, Jesse

AU - Steinhart, Brian

AU - Udell, Jacob A.

AU - Wijeysundera, Harindra C.

AU - Atkinson, Paul

AU - Campbell, Samuel G.

AU - Chandra, Kavish

AU - Cox, Jafna L.

AU - Mulvagh, Sharon

AU - Quraishi, Ata ur Rehman

AU - Chen-Tournoux, Annabel

AU - Clark, Gregory

AU - Segal, Eli

AU - Suskin, Neville

AU - Johri, Amer M.

AU - Sivilotti, Marco L.A.

AU - Garuba, Habibat

AU - Thiruganasambandamoorthy, Venkatesh

AU - Robinson, Simon

AU - Scheuermeyer, Frank

AU - Humphries, Karin H.

AU - Than, Martin

AU - Pickering, John W.

AU - Worster, Andrew

AU - Mills, Nicholas L.

AU - Devereaux, P. J.

AU - Jaffe, Allan S.

N1 - Funding Information: Special thanks for the following individuals who helped in this prospective study: Chantele Roy, Paul Malinowski, and Tara Bryce (CRLB-GMEL, Hamilton Health Sciences, Hamilton, ON); Nadia Caruso (Juravinski Hospital and Cancer Centre, Hamilton ON); Vathany Kulasingam (University Health Network, Toronto, ON); Mark Cheung (Sunnybrook Hospital, Toronto, ON); Viktor Skihar, Joshua Buse, Jan Feser, and Christina Bacalso (Regina General Hospital, Regina, SK); Janet Simons and Laura Burns (St Paul's Hospital, Vancouver, BC); Allyse Hummelman (Mount Saint Joseph Hospital, Vancouver, BC); Jennifer Annand, Robyn Dahl, and Sabrina Hocken (Victoria General Hospital, Victoria, BC); Marisa Schneider, Maryann Jiang, and Darryl Holden (Royal Jubilee Hospital, Victoria, BC); Krista McComb, Eric (Phong) Ly, Carmen Zimmer, and Christina Gauvreau (University of Alberta Hospital, Edmonton, AB); Rob Saunders (St Paul's Hospital, Saskatoon, SK); Connie, Neuberger and Karen Nogier (Royal University Hospital, Saskatoon, SK); Kari Henwood, Jeffrey Noel, and JoAnne Novakowski (St. Boniface Hospital, Winnipeg, MB); Debbie Kiel and Meghan Rasmussen (Selkirk Regional Health Centre, Selkirk, MB); Katie Ndukwu and Steven Cong (Health Sciences Centre,Winnipeg, MB); Roy Augustin and Fari Rokhforooz (Mount Sinai Hospital, Toronto, ON); Bonny Lem Ragosnig and Liyan Ma (Sunnybrook Hospital, Toronto, ON); Sarah Lam (Toronto General Hospital, Toronto, ON); Julia (Qiu Yi) Shao (St Michael's Hospital, Toronto, ON); Robert Dean and Leanne Reilly (Kingston General Hospital, Kingston, ON); Emma Greenough, Isla Craig, and Alan Burgess (Ottawa Hospital—Civic Campus, Ottawa, ON); Sarah Cascanette, Janette Rutledge, Guylaine Imbeault, and Sandy Bookalam (Ottawa Hospital—General Campus, Ottawa, ON); Purvi Patel (Brampton Civic Hospital, Brampton ON); Linda Stevenson (Etobicoke General Hospital, Etobicoke, ON); Lisa Brown (Peel Memorial Centre for Integrated Health and Wellness, Brampton, ON); Husam Abdoh (LHSC—Victoria Hospital, London, ON); Bill Richardson, Kylie, McInerney, and Rick Moore (LHSC—University Hospital, London, ON); Nathalie Payette, Gloria Marcaida, Kruno Lorkovic, and Maryse Coderre (Hopital General de Montréal, Montréal, QC); Lisa Murphy, Maia Stallone, and Ana Marcaida (Le Site Glen, Montréal, QC), Micheline Masangya (St Mary's Hospital Center, Montréal, QC); Youcef Amimer (Institut de Cardiologie, de Montréal, Montréal, QC); Rianne Madriaga, Oktavian Toka, Safiya Sweeney, and Girupan Arasaratman (Jewish General Hospital, Montréal, QC), Ashley Stevens, Tiffany Moore, and Christina Quondam Franks (Saint John Regional Hospital, Saint John, NB); Ian MacLean, Sandy Schlay, and Rebecca Reid (Queen Elizabeth II Health Sciences Centre, Halifax, NS); Kathleen Lawrence and Kelly Smith (Dartmouth General Hospital, Dartmouth, NS); Rose Bartlett, Craig Leblanc, Shelley Strong, and Shannah Hynes (Cobequid Community Health Centre, Lower Sackville, NS); Kimberly Ross and Jenilee Calbury (Hants Community Hospital, Windsor, NS); Trish Jarvie, Jill Boreyko, Ronda Snowdy, Binal Parikhb, and Trisha Bellamy (Hamilton General Hospital, Hamilton, ON); Ching Mark, Elspeth Millar, Brian Vandermey, and Leesa Lillie (Juravinski Hospital and Cancer Centre, Hamilton, ON); Matthew Hulett and Glen Edmunds (West Lincoln Memorial Hospital, Grimsby, ON); and the CODE-MI study. Funding was provided by a grant from the Canadian Institutes of Health Research (to Dr Kavsak) and a Chair Award, Programme Grant, and Research Excellence Award (CH/F/21/90010, RG/20/10/34966, RE/18/5/34216) from the British Heart Foundation (to Dr Mills). The funding organisations had no role in the design and conduct of the study; in the collection, analysis, and interpretation of the data; or in the final approval of the manuscript. See Supplemental Appendix S1 for disclosures. Funding Information: Funding was provided by a grant from the Canadian Institutes of Health Research (to Dr Kavsak) and a Chair Award, Programme Grant, and Research Excellence Award (CH/F/21/90010, RG/20/10/34966, RE/18/5/34216) from the British Heart Foundation (to Dr Mills). The funding organisations had no role in the design and conduct of the study; in the collection, analysis, and interpretation of the data; or in the final approval of the manuscript.

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Y1 - 2023/7

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Analytic Result Variation for High-Sensitivity Cardiac Troponin: Interpretation and Consequences

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