Analysis and interpretation of results based on patient-reported outcomes

Jeff A. Sloan, Amylou C. Dueck, Pennifer A. Erickson, Harry Guess, Dennis A. Revicki, Nancy C. Santanello

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


This article is part of a series of manuscripts dealing with the incorporation of patient-reported outcomes (PROs) into clinical trials. The issues dealt with in this manuscript concern the common pitfalls to avoid in statistical analysis and interpretation of PROs. Specifically, the questions addressed by this manuscript involve the analysis pitfalls with PRO data in clinical trials and how can they be avoided (e.g.,missing data, multiplicity, null results etc.). The manuscript provides key literature for existing resources and proposes new guidelines.

Original languageEnglish (US)
Pages (from-to)S106-S115
JournalValue in Health
Issue numberSUPPL. 2
StatePublished - 2007


  • Clinical significance
  • Minimally important difference
  • Missing data
  • Patient-reported outcomes
  • Statistical analysis

ASJC Scopus subject areas

  • Health Policy
  • Public Health, Environmental and Occupational Health


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