An update on primary drug therapies for Alzheimer disease

David S. Knopman, John C. Morris

Research output: Contribution to journalReview articlepeer-review

36 Scopus citations


Propelled by remarkable advances in the understanding of the pathological characteristics of Alzheimer disease (AD), the prospects for the treatment of the clinical disorder have brightened considerably in the past decade. Primary treatment is aimed at the core elements of AD: memory and other cognitive loss at the symptomatic level and the pathological characteristics of molecular, cellular, and neural systems at the biological level. Behavioral features, such as depression, delusions, anxiety, disordered sleep, and agitation, are considered secondary manifestations of AD, although these features have a major impact on the quality of life, functional effectiveness, and caregiver burden. The focus of this review is on recent developments in the primary therapy for AD.

Original languageEnglish (US)
Pages (from-to)1406-1409
Number of pages4
JournalArchives of neurology
Issue number11
StatePublished - Nov 1997

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology


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