@article{20aa07b2050a4794ba4005c06c2f42b7,
title = "An international multidisciplinary consensus statement on the prevention of opioid-related harm in adult surgical patients",
abstract = "This international multidisciplinary consensus statement was developed to provide balanced guidance on the safe peri-operative use of opioids in adults. An international panel of healthcare professionals evaluated the literature relating to postoperative opioid-related harm, including persistent postoperative opioid use; opioid-induced ventilatory impairment; non-medical opioid use; opioid diversion and dependence; and driving under the influence of prescription opioids. Recommended strategies to reduce harm include pre-operative assessment of the risk of persistent postoperative opioid use; use of an assessment of patient function rather than unidimensional pain scores alone to guide adequacy of analgesia; avoidance of long-acting (modified-release and transdermal patches) opioid formulations and combination analgesics; limiting the number of tablets prescribed at discharge; providing deprescribing advice; avoidance of automatic prescription refills; safe disposal of unused medicines; reducing the risk of opioid diversion; and better education of healthcare professionals, patients and carers. This consensus statement provides a framework for better prescribing practices that could help reduce the risk of postoperative opioid-related harm in adults.",
keywords = "deprescribing, guidelines, opioid-induced ventilatory impairment, opioids, peri-operative, persistent postoperative opioid use",
author = "N. Levy and J. Quinlan and K. El-Boghdadly and Fawcett, {W. J.} and V. Agarwal and Bastable, {R. B.} and Cox, {F. J.} and {de Boer}, {H. D.} and Dowdy, {S. C.} and K. Hattingh and Knaggs, {R. D.} and Mariano, {E. R.} and P. Pelosi and Scott, {M. J.} and Lobo, {D. N.} and Macintyre, {P. E.}",
note = "Funding Information: NL and JQ contributed equally to this manuscript and share first authorship. DL and PM contributed equally to this manuscript and share senior authorship. NL is a co‐author on peri‐operative opioid guidelines of the Royal College of Anaesthetists. KE has received honoraria, educational, travel and/or research funding from Fisher and Paykel Healthcare Ltd., Ambu and GE Healthcare for unrelated work. KE is an Editor for . WF has received speaker's honoraria from Grunethal, Baxter, MSD and Smiths. He has also received book royalties from Cambridge University Press for unrelated work. RB owns shares in Astra Zeneca. She has also contributed to peri‐operative opioid guidelines of the Royal College of Anaesthetists. FC has acted as an advisor and speaker for Grunenthal UK, Napp Pharmaceuticals Ltd, and Pfizer. She has also acted as an advisor to Kyowa Kirin. HdB has received research grants and funding from Merck, Fresenius Kabi and MDoloris for unrelated work. RK is a Council Member of the Advisory Council on the Misuse of Drugs, Vice President of the British Pain Society and is a member of the Medicines Advisory Group of the Faculty of Pain Medicine. He has also contributed to peri‐operative opioid guidelines of the Royal College of Anaesthetists. MS is on the Advisory Boards of Merck, Baxter, Trevena and Edwards Lifescience. DL has received unrestricted research funding from B. Braun and speaker's honoraria from Fresenius Kabi, B. Braun, Shire and Baxter Healthcare for unrelated work. PM has received book royalties from CRC Press. No other external funding or competing interests declared. Anaesthesia Funding Information: NL and JQ contributed equally to this manuscript and share first authorship. DL and PM contributed equally to this manuscript and share senior authorship. NL is a co-author on peri-operative opioid guidelines of the Royal College of Anaesthetists. KE has received honoraria, educational, travel and/or research funding from Fisher and Paykel Healthcare Ltd., Ambu and GE Healthcare for unrelated work. KE is an Editor for Anaesthesia. WF has received speaker's honoraria from Grunethal, Baxter, MSD and Smiths. He has also received book royalties from Cambridge University Press for unrelated work. RB owns shares in Astra Zeneca. She has also contributed to peri-operative opioid guidelines of the Royal College of Anaesthetists. FC has acted as an advisor and speaker for Grunenthal UK, Napp Pharmaceuticals Ltd, and Pfizer. She has also acted as an advisor to Kyowa Kirin. HdB has received research grants and funding from Merck, Fresenius Kabi and MDoloris for unrelated work. RK is a Council Member of the Advisory Council on the Misuse of Drugs, Vice President of the British Pain Society and is a member of the Medicines Advisory Group of the Faculty of Pain Medicine. He has also contributed to peri-operative opioid guidelines of the Royal College of Anaesthetists. MS is on the Advisory Boards of Merck, Baxter, Trevena and Edwards Lifescience. DL has received unrestricted research funding from B. Braun and speaker's honoraria from Fresenius Kabi, B. Braun, Shire and Baxter Healthcare for unrelated work. PM has received book royalties from CRC Press. No other external funding or competing interests declared. Publisher Copyright: {\textcopyright} 2020 Association of Anaesthetists",
year = "2021",
month = apr,
doi = "10.1111/anae.15262",
language = "English (US)",
volume = "76",
pages = "520--536",
journal = "Anaesthesia",
issn = "0003-2409",
publisher = "Wiley-Blackwell",
number = "4",
}